{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:04:11Z","timestamp":1785434651340,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["ID 101390"],"award-info":[{"award-number":["ID 101390"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["ID 20045"],"award-info":[{"award-number":["ID 20045"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["ID 125132"],"award-info":[{"award-number":["ID 125132"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cardiovascular control during exercise is impaired in chronic obstructive pulmonary disease (COPD). The central cardiopulmonary pathologies in COPD might drive the local muscle vascular abnormalities. We hypothesised that contracting muscle perfusion and O\n                    <jats:sub>2<\/jats:sub>\n                    utilisation improve after lung transplantation (LTx) in COPD. Ten patients with end\u2010stage COPD were tested on the LTx waiting list (pre\u2010LTx) and again 6 months after LTx (post\u2010LTx). We measured leg blood flow (, main outcome) during submaximal one\u2010leg knee\u2010extensor exercise (KEE), and femoral arterial\u2013venous blood samples were obtained for the determination of O\n                    <jats:sub>2<\/jats:sub>\n                    kinetics across the leg and vasoactive compounds. Cardiac output and stroke volume in response to KEE peak workload (WL\n                    <jats:sub>peak<\/jats:sub>\n                    ), walking distance and physical activity (triaxial accelerometry) were also assessed. Lung function (one single and nine double LTx), walking distance and physical activity increased post\u2010LTx, whereas leg lean mass and WL\n                    <jats:sub>peak<\/jats:sub>\n                    remained unchanged. Arterial oxygen partial pressure decreased in response to KEE pre\u2010LTx but was maintained at resting levels post\u2010LTx. Working muscle capillary O\n                    <jats:sub>2<\/jats:sub>\n                    tension and saturation were also higher post\u2010LTx, with no difference in muscle O\n                    <jats:sub>2<\/jats:sub>\n                    conductance or extraction. We found no changes in  during submaximal KEE (pre\u2010LTx: 1026\u00a0\u00b1\u00a0278 vs. post\u2010LTx: 941\u00a0\u00b1\u00a0186 mL\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.49); mean arterial pressure and circulating pro\u2010brain natriuretic peptide levels were lower post\u2010LTx and cardiac output higher. Cardiac output (pre\u2010LTx: 6.1\u00a0\u00b1\u00a00.4 vs. post\u2010LTx: 8.3\u00a0\u00b1\u00a00.5 L\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0001) and stroke volume responses to WL\n                    <jats:sub>peak<\/jats:sub>\n                    were also higher post\u2010LTx. LTx did not affect muscle blood flow regulation during moderate\u2010intensity KEE in end\u2010stage COPD and seemed to be disconnected from the augmented cardiac output responses to exercise.\n                  <\/jats:p>","DOI":"10.1113\/ep093645","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:09:38Z","timestamp":1784077778000},"page":"3604-3619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Haemodynamic responses to small muscle mass exercise before and after lung transplantation in end\u2010stage chronic obstructive pulmonary disease"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-7331","authenticated-orcid":false,"given":"Camilla Koch","family":"Ryrs\u00f8","sequence":"first","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-3136","authenticated-orcid":false,"given":"Thomas Kromann","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Section for Lung Transplantation Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Thaning","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Respiratory Medicine University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Gliemann","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human Physiology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Perch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Section for Lung Transplantation Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Peter","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida K\u00e6r","family":"Thorsen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregers Winding","family":"Munch","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-9558","authenticated-orcid":false,"given":"Ylva","family":"Hellsten","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human Physiology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-9506","authenticated-orcid":false,"given":"Ronan M. G.","family":"Berg","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-2583","authenticated-orcid":false,"given":"Ulrik Winning","family":"Iepsen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital\u2013Hvidovre  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00239-2023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.5.1647"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202312-1062OC"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091560"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279135"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04146-2020"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00193411"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00156.2002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP088615"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00494"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.2.9032203"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.078980"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00053512"},{"issue":"7","key":"e_1_2_11_15_1","article-title":"Exercise training for adult lung transplant recipients","volume":"7","author":"Gutierrez\u2010Arias R.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282972"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.979359"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00058.2024"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00798.2024"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.2.560"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.6.7767529"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091645"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S114351"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00178.2017"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00398.2017"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0319ED"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12678"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-2140CI"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.2000.10474559"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00225.2010"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.07.005"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201402-0373ST"},{"issue":"2","key":"e_1_2_11_33_1","article-title":"Pulmonary rehabilitation for chronic obstructive pulmonary disease","volume":"2015","author":"McCarthy B.","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201307-229OC"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735611"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-021-04854-7"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00042702"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.102327"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200305-627OC"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118237"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9803049"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00184.2015"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13227"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00877.2018"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.2196\/30602"},{"issue":"12","key":"e_1_2_11_46_1","first-page":"1231","article-title":"Metabolic myopathy as a cause of the exercise limitation in lung transplant recipients","volume":"17","author":"Tirdel G. B.","year":"1998","journal-title":"Journal of Heart and Lung Transplantation"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101185"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S280540"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0116-2022"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0172OC"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-1955-7"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9805092"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.12.007"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP093645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:44:31Z","timestamp":1785433471000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP093645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1113\/EP093645"],"URL":"https:\/\/doi.org\/10.1113\/ep093645","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}