{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:26:07Z","timestamp":1786119967001,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017481","name":"Chukyo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017481","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012002","name":"Descente and Ishimoto Memorial Foundation for the Promotion of Sports Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prolonged sitting disrupts lower\u2010limb endothelial and microvascular function, likely via reduced shear stress and blunted microvascular reactivity. We examined whether Tabata\u2010style high\u2010intensity interval training (HIIT) mitigates this sitting\u2010induced vascular dysfunction. Twenty\u2010two healthy young adults (age 20.3\u00a0\u00b1\u00a00.8 years) were randomly assigned to a control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011) or a training group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011); each group comprised seven men and four women. Participants completed 8\u00a0weeks of HIIT (4 sessions\/week) using a cycle ergometer and bodyweight exercises. Before and after the intervention, participants underwent a 3\u00a0h period of sitting during which popliteal artery flow\u2010mediated dilation (FMD) and reactive hyperaemic blood flow were assessed; plasma nitrate\/nitrite and endothelin\u20101 were also measured at rest. Sitting reduced popliteal artery blood flow and shear rate in both groups before and after training (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Popliteal artery FMD decreased after sitting at baseline in both groups and remained lower after sitting in the training group post\u2010intervention. However, post\u2010sitting FMD at week 8 was higher in the HIIT group than in controls after adjustment for pre\u2010sitting FMD. Post\u2010sitting blood\u2010flow area under the curve was decreased by sitting in both groups before and after the intervention (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), and resting nitrate\/nitrite and endothelin\u20101 did not change with training. These results indicate that 8\u00a0weeks of HIIT does not prevent sitting\u2010induced impairments in endothelial function or microvascular function. Although the HIIT maintained higher post\u2010sitting FMD, HIIT alone was insufficient to counteract the acute endothelial and microvascular dysfunction imposed by sitting.\n                  <\/jats:p>","DOI":"10.1113\/ep093646","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:40:32Z","timestamp":1777308032000},"page":"3242-3252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eight weeks of high\u2010intensity interval training is insufficient to prevent sitting\u2010induced endothelial dysfunction and microvascular impairment"],"prefix":"10.1113","volume":"111","author":[{"given":"Nobukazu","family":"Kasai","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences Aichi Shukutoku University  Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Ihara","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences Aichi Shukutoku University  Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Iemitsu","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Science Ritsumeikan University  Kusatsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-1479","authenticated-orcid":false,"given":"Takuma","family":"Morishima","sequence":"additional","affiliation":[{"name":"Faculty of Liberal Arts and Sciences Chukyo University  Nagoya Aichi 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