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Fourteen healthy adults (24\u00a0\u00b1\u00a04 years; 1.81\u00a0\u00b1\u00a00.06\u00a0m; 75\u00a0\u00b1\u00a012\u00a0kg) completed an incremental jumping test in simulated lunar gravity (9.5\u00b0 head\u2010up tilt suspension) followed by a graded exercise test to determine maximal oxygen uptake (). Two exercise visits (with and without BFR) were completed on separate days comprising 6\u00a0\u00d7\u00a02\u00a0min of low\u2010intensity (40% ) continuous jumping at \u223c20% bodyweight, with 1\u2010min passive rest periods. Blood flow restriction was applied at 60% limb occlusion pressure to the lower limbs during the exercise periods and removed during the rest periods. Jumping in simulated lunar gravity with BFR, compared to without BFR, significantly decreased muscle tissue oxygenation within the vastus lateralis (\u223c20%) and gastrocnemius medialis (\u223c5%), and increased heart rate (10\u201323\u00a0beats min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), carbon dioxide output (2\u20134\u00a0mL\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and minute ventilation (7\u201316 L\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Oxygen consumption was either unaffected or slightly elevated up to 3\u00a0mL\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Blood lactate concentration was significantly greater during BFR jumping by \u223c1\u20132\u00a0mmol\u00a0L\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Pre\u2013post exercise knee extension peak force declined in both conditions to similar extents. Perceived exertion, discomfort and body instability significantly increased with BFR. Jumping in simulated lunar gravity with BFR requires little equipment and elicits similar metabolic, cardiovascular and perceptual responses to BFR aerobic exercise in terrestrial settings (e.g., BFR walking\/cycling), and therefore may have value as a musculoskeletal and cardiovascular exercise countermeasure during planetary exploration missions.\n                  <\/jats:p>","DOI":"10.1113\/ep093652","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:12:31Z","timestamp":1781691151000},"page":"3699-3717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-7578","authenticated-orcid":false,"given":"Patrick","family":"Swain","sequence":"first","affiliation":[{"name":"Aerospace Medicine and Rehabilitation Laboratory, School of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica, Faculdade de Ci\u00eancias Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Caplan","sequence":"additional","affiliation":[{"name":"Aerospace Medicine and Rehabilitation Laboratory, School of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Latue","sequence":"additional","affiliation":[{"name":"Aerospace Medicine and Rehabilitation Laboratory, School of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie","family":"Illingworth","sequence":"additional","affiliation":[{"name":"Aerospace Medicine and Rehabilitation Laboratory, School of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Sheard","sequence":"additional","affiliation":[{"name":"Aerospace Medicine and Rehabilitation Laboratory, School of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-1319","authenticated-orcid":false,"given":"Luke","family":"Hughes","sequence":"additional","affiliation":[{"name":"Aerospace Medicine and Rehabilitation Laboratory, School of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.08.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3357\/AMHP.4332.2015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3357\/AMHP.4399.2016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3357\/AMHP.5307.2019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-024-00759-9"},{"key":"e_1_2_10_8_1","volume-title":"Borg's perceived exertion and pain scales","author":"Borg G.","year":"1998"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","unstructured":"Burke C. 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