{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:19:26Z","timestamp":1783055966408,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1170963"],"award-info":[{"award-number":["1170963"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1180157"],"award-info":[{"award-number":["1180157"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1220293"],"award-info":[{"award-number":["1220293"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"Abstract<\/jats:title>\n \n High\u2010intensity endurance exercise induces myocardial remodelling as an adaptive response to sustained volume overload, but excessive cumulative training might also favour deleterious cardiac remodelling, including atrial fibrosis. Whether acute marathon running engages circulating fibrosis\u2010related biomarkers and whether these biomarkers track with atrial function in a training volume\u2010dependent manner remains unclear. This study, with within\u2010subject pre\u2010 and post\u2010marathon comparisons, evaluated plasma galectin\u20103 and amino\u2010terminal type III procollagen propeptide (PIIINP) in 36 male long\u2010distance runners before and immediately after completion of a marathon and examined their relationship to atrial function assessed by speckle\u2010tracking echocardiography. Participants were stratified into high\u2010training (HT; \u2265100\u00a0km\u00a0week\n \u22121<\/jats:sup>\n ;\n n<\/jats:italic>\n \u00a0=\u00a018) and low\u2010training (LT; <100\u00a0km\u00a0week\n \u22121<\/jats:sup>\n ;\n n<\/jats:italic>\n \u00a0=\u00a018) groups, with 18 age\u2010matched non\u2010active control subjects. At baseline, galectin\u20103, PIIINP, left atrial strain a wave (LASa) and right atrial strain a wave (RASa) were comparable across groups. Marathon completion significantly increased galectin\u20103 [mean (SD): LT, from 5.2 (2.3) to 23.1 (8.2) ng\u00a0mL\n \u22121<\/jats:sup>\n ; HT, from 7.2 (3.8) to 26.5 (11.0) ng\u00a0mL\n \u22121<\/jats:sup>\n ; both\n P<\/jats:italic>\n \u00a0<\u00a00.001] and PIIINP in both runner groups. The pre\u2010to\u2010post fractional changes in galectin\u20103 and PIIINP were moderately correlated when all runners were considered together (\n r<\/jats:italic>\n \u00a0=\u00a00.569,\n P<\/jats:italic>\n \u00a0=\u00a00.006). In exploratory correlation analyses, the post\u2010marathon galectin\u20103 fractional change was positively correlated with the post\u2010marathon LASa across all runners (\n r<\/jats:italic>\n \u00a0=\u00a00.413,\n P<\/jats:italic>\n \u00a0=\u00a00.015), indicating that larger increases in galectin\u20103 were associated with less negative atrial strain values; subgroup analysis indicated that this association was driven by the highly trained athletes (HT,\n r<\/jats:italic>\n \u00a0=\u00a00.476,\n P<\/jats:italic>\n \u00a0=\u00a00.045); the corresponding correlation did not reach significance in the LT group (\n r<\/jats:italic>\n \u00a0=\u00a00.378,\n P<\/jats:italic>\n \u00a0=\u00a00.148). No such association was observed for PIIINP or for the RASa in any group. These findings suggest that the acute galectin\u20103 response to marathon running might be linked to left atrial contractile function selectively in highly trained athletes.\n <\/jats:p>","DOI":"10.1113\/ep093665","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:52:00Z","timestamp":1783054320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Galectin\u20103 plasma levels are associated with left atrial contractile function in long\u2010distance runners"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0674-7506","authenticated-orcid":false,"given":"Felipe","family":"Contreras\u2010Brice\u00f1o","sequence":"first","affiliation":[{"name":"Instituto de Ciencias de la Salud Universidad de O'Higgins Rancagua Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8592-7598","authenticated-orcid":false,"given":"Fernanda","family":"Sanhueza\u2010Olivares","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas Universidad de Chile Santiago Chile"},{"name":"Unidad de Investigaci\u00f3n Cient\u00edfica Hospital Base San Jos\u00e9 Osorno Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Cient\u00edfica Hospital Base San Jos\u00e9 Osorno Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Llevaneras","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"Laboratorio de Cardiolog\u00eda, Red de Salud UC Christus Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-1703","authenticated-orcid":false,"given":"Pablo F.","family":"Castro","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"Laboratorio de Cardiolog\u00eda, Red de Salud UC Christus Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-7147","authenticated-orcid":false,"given":"Luigi","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"Laboratorio de Cardiolog\u00eda, Red de Salud UC Christus Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5174-6545","authenticated-orcid":false,"given":"Mario","family":"Chiong","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1161\/CIRCULATIONAHA.110.938282","article-title":"Cardiac arrhythmogenic remodeling in a rat model of long\u2013term intensive exercise training","volume":"123","author":"Benito B.","year":"2011","journal-title":"Circulation"},{"issue":"24","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull F. 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