{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:07:39Z","timestamp":1785434859331,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","award":["4000113871\/15\/NL\/PG"],"award-info":[{"award-number":["4000113871\/15\/NL\/PG"]}],"id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000104","name":"National Aeronautics and Space Administration","doi-asserted-by":"publisher","award":["80JSC018P0078"],"award-info":[{"award-number":["80JSC018P0078"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["29801"],"award-info":[{"award-number":["29801"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prolonged physical inactivity alters the cardiovascular system, including the heart. Long\u2010term bed rest is known to decrease left ventricular volume and cause diastolic dysfunction; however, the interplay between these changes and their effect on cardiac contractility have been understudied. Here we used novel non\u2010invasive imaging techniques to longitudinally assess changes in regional cardiac contractility and function that can occur prior to the development of overt cardiac changes. Specifically, we performed cardiac magnetic resonance imaging on 24 healthy participants before, during, and after 60 days of strict head\u2010down tilt bed rest (AGBRESA) to measure intracardiac haemodynamic forces and left\u2010ventricular inward displacements via dedicated software. The integrated left ventricular haemodynamic force as well as the ejection force during systole were reduced throughout the bed rest. While maximal diastolic deceleration (at the E\u2010wave) significantly decreased during bed rest, left ventricular diastolic suction and maximal value for the late diastolic deceleration phase were significantly increased. Inward displacement analysis showed that motion of the cardiac base was significantly reduced after bed rest, whereas apical motion was significantly increased. The analysis of haemodynamic forces and regional cardiac inward displacement are novel non\u2010invasive imaging readouts that can provide longitudinal information about cardiac contractility and function. Our study highlights that prolonged bed rest alters regional cardiac motion and haemodynamic forces, with a desynchrony in contractile alterations to maintain cardiac filling during diastole.<\/jats:p>","DOI":"10.1113\/ep093671","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:43:38Z","timestamp":1782801818000},"page":"3570-3587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apical hypercontractility mitigates impaired diastolic filling and lower intraventricular haemodynamic forces in human bed rest"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-075X","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Rabineau","sequence":"first","affiliation":[{"name":"LPHYS, Department of Cardiology Universit\u00e9 Libre de Bruxelles  Bruxelles Belgium"},{"name":"Department of Kinesiology and Health Sciences University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-2669","authenticated-orcid":false,"given":"Fatimah","family":"Al\u2010Darwish","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics, Amsterdam Cardiovascular Sciences, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1200-5792","authenticated-orcid":false,"given":"Edwin","family":"Mulder","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-653X","authenticated-orcid":false,"given":"Bram F.","family":"Coolen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics, Amsterdam Cardiovascular Sciences, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hautemann","sequence":"additional","affiliation":[{"name":"MEDIS  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5672-1187","authenticated-orcid":false,"given":"Jens","family":"Tank","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-7154","authenticated-orcid":false,"given":"Pierre\u2010Fran\u00e7ois","family":"Migeotte","sequence":"additional","affiliation":[{"name":"LPHYS, Department of Cardiology Universit\u00e9 Libre de Bruxelles  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-5058","authenticated-orcid":false,"given":"Gustav J.","family":"Strijkers","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics, Amsterdam Cardiovascular Sciences, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-5177","authenticated-orcid":false,"given":"Rob C. I.","family":"W\u00fcst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics, Amsterdam Cardiovascular Sciences, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences Vrije Universiteit  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08023-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00583.2016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00112.2018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00122.2014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00142.2012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.067488"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-022-02631-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-021-02435-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00858.2006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101372"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12685"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-01934-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245937"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2141"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00019.2012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd10120474"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12051997"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13072"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac205"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwac029"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2281.1997.02626.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-021-04673-w"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.11.019"},{"issue":"2","key":"e_1_2_9_26_1","first-page":"377","article-title":"The intraventricular hemodynamic forces estimated using routine CMR cine images: A new marker of the failing heart","volume":"12","author":"Lapinskas T.","year":"2019","journal-title":"Journal of the American College of Cardiology Cardiovasc Imaging"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwac125"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.517"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2025.133773"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-023-02861-7"},{"issue":"1","key":"e_1_2_9_31_1","first-page":"69","article-title":"Effects of reducing sedentary behaviour on cardiac structure and function at rest and during exercise: A 6\u2010month randomized controlled trial","volume":"8","author":"Norha J.","year":"2026","journal-title":"Canadian Journal of Cardiology Open"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090103"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.06.046"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.2.645"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.944587"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.01.033"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.2526.2010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-025-00531-7"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023417"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab294"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311756"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084100"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP093671","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:45:25Z","timestamp":1785433525000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP093671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1113\/EP093671"],"URL":"https:\/\/doi.org\/10.1113\/ep093671","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2026-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}