{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:46:57Z","timestamp":1791704817849,"version":"4.3.4"},"reference-count":78,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accumulation of \u223c200\u00a0h of hypoxia exposure (pre\u2010acclimatization) has been suggested to prevent the development of acute mountain sickness when a person is subsequently exposed to high altitude. These pre\u2010exposures are typically undertaken intermittently at or near the place of residence, primarily during sleep in hypoxic tents, and are likely to induce effective ventilatory acclimatization. However, the physiological consequences of different modes of intermittent hypoxia (IH) exposure on ventilatory acclimatization remain largely obscure and are the subject of much controversy. The aim of this review is therefore to summarize and discuss the findings of relevant studies and draw on our long\u2010term practical experience to address the effects of IH exposure on ventilatory acclimatization and to provide suggestions for effective pre\u2010acclimatization. We provide a balanced overview of studies investigating the effects of different types of altitude\/hypoxia exposure on the hypoxic ventilatory response and renal compensation to hyperventilation\u2010induced respiratory alkalosis. Although it has been demonstrated convincingly that the hypoxic ventilatory response can increase by 50%\u2013100% with only a few short IH sessions (1\u00a0h per day for 7 days), the available data on the effects of IH on renal compensation do not permit definitive conclusions to be drawn. Long\u2010term exposure to IH over several weeks appears to induce renal compensation effectively, allowing for a full ventilatory response and favourable oxygenation at high altitude. To clarify definitively which strategies are most suitable, long\u2010term systematic investigations of various IH strategies are urgently needed.<\/jats:p>","DOI":"10.1113\/ep093689","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:29:58Z","timestamp":1791703798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent hypoxia interventions for inducing ventilatory acclimatization to high altitude?"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-3632","authenticated-orcid":false,"given":"Martin","family":"Burtscher","sequence":"first","affiliation":[{"name":"Department of Sport Science University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-657X","authenticated-orcid":false,"given":"Axel","family":"Kleinsasser","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Critical Care Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Burtscher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Psychotherapy, Psychosomatics and Medical Psychology University Hospital for Psychiatry II Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"H\u00fcfner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Psychotherapy, Psychosomatics and Medical Psychology University Hospital for Psychiatry II Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik R.","family":"Swenson","sequence":"additional","affiliation":[{"name":"Department of Medicine Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hackett","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-2930","authenticated-orcid":false,"given":"Hannes","family":"Gatterer","sequence":"additional","affiliation":[{"name":"Institute of Mountain Emergency Medicine Eurac Research  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s00421-026-06135-7","article-title":"Impact of hypoxic air quality on resistance training effect in different normobaric hypoxia environments","volume":"126","author":"Abril J.","year":"2026","journal-title":"European Journal of Applied Physiology"},{"issue":"6","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1152\/japplphysiol.01167.2010","article-title":"High\u2010altitude exposure of three weeks duration increases lung diffusing capacity in humans","volume":"110","author":"Agostoni P.","year":"2011","journal-title":"Journal of Applied Physiology"},{"issue":"1","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146087","article-title":"Ibuprofen blunts ventilatory acclimatization to sustained hypoxia in humans","volume":"11","author":"Basaran K. 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