{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:25:20Z","timestamp":1786119920407,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","award":["4000138718\/22\/NL\/DB"],"award-info":[{"award-number":["4000138718\/22\/NL\/DB"]}],"id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Artificial gravity (AG) combined with resistive vibration exercise has been proposed as a multi\u2010system countermeasure for long\u2010duration spaceflight; however, its operational feasibility during prolonged unloading remains insufficiently characterised. This study primarily evaluated the feasibility, tolerability, and adherence to a structured resistive vibration exercise protocol delivered either under artificial gravity (AGRVE) or in horizontal loading (HRVE) during 60\u00a0days of hypoxic (\u00a0=\u00a00.14) 6\u00b0 head\u2010down tilt bed rest. Secondary observations included delayed\u2010onset muscle soreness (DOMS) and changes in eight\u2010repetition maximum strength (8RM) to inform load progression. Sixteen healthy male participants were allocated to HRVE (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a09) or AGRVE (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a08) and completed near\u2010daily 30\u2010min training sessions at light (30% 1RM) and moderate (50% 1RM) intensities. Adherence was high in both groups (HRVE: 98.5%; AGRVE: 96.3%). In AGRVE, early\u2010session interruptions were primarily due to motion sickness or presyncopal symptoms; motion sickness severity declined significantly across repeated centrifugation exposures (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), consistent with vestibular habituation. HRVE interruptions were predominantly fatigue\u2010related. DOMS remained low throughout the intervention (typically 0\u20133\/10). 8RM increased over time in both groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Progressive resistive vibration exercise can be implemented with high adherence during prolonged hypoxic bed rest, including when combined with AG. Motion sickness represents the principal early operational constraint specific to squat\u2010based AG exposure but diminishes with repeated sessions.\n                  <\/jats:p>","DOI":"10.1113\/ep093699","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:40:13Z","timestamp":1779986413000},"page":"3152-3172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of and adherence to artificial gravity and resistive vibration exercises during 60\u00a0days of hypoxic 6\u00b0 head\u2010down tilt bed rest: BRAVE study"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7346-5874","authenticated-orcid":false,"given":"Jack","family":"Fortune","sequence":"first","affiliation":[{"name":"Department of Automatics, Biocybernetics and Robotics Jo\u017eef Stefan Institute  Ljubljana Slovenia"},{"name":"Jo\u017eef Stefan International Postgraduate 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