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The aim of this study was to provide pilot evidence for possible utilization of a sensorized patch for capturing the bodily response to hypoxia. The subsequent phases of the study comprised a case report and a case series, with participants undergoing physical tests in both normobaric normoxia and hypoxia. The data obtained from VitalPatch\u00ae were compared with data from the metabolic cart COSMED Quark CPET. In the case report, agreement was substantial for heart rate (HR) and poor for respiratory rate (RR) in an incremental normoxic test, and almost perfect for HR and moderate for RR in a time\u2010to\u2010exhaustion hypoxic test; in the case series, agreement was substantial for HR and poor for RR. The trend of values generally was almost superimposable and mean bias was overall acceptable. ECG alarms were considered mostly false or highly uncertain, possibly due to noise and artifacts. The quality of the recording was unaffected by the presence of hypoxia. VitalPatch\u00ae is best used at rest and in minimal movement, offering reliable HR and RR monitoring.<\/jats:p>","DOI":"10.1113\/ep093718","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T02:05:47Z","timestamp":1780193147000},"page":"3280-3293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancing tele\u2010physiology: A chest patch solution for continuous, non\u2010invasive remote monitoring in a hypoxic environment"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-3606","authenticated-orcid":false,"given":"Danilo","family":"Bondi","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Imaging and Clinical Sciences University \u2018G. d'Annunzio\u2019 Chieti \u2010 Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1351-6382","authenticated-orcid":false,"given":"Ferdinando","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine University of Verona  Verona Italy"},{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Fioraso","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"},{"name":"Sport, Mountain and Health Research Centre (CeRiSM) University of Verona and University of Trento  Rovereto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-6989","authenticated-orcid":false,"given":"Camillo","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Department of Science University \u201cG. d'Annunzio\u201d Chieti \u2010 Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Schena","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"},{"name":"Sport, Mountain and Health Research Centre (CeRiSM) University of Verona and University of Trento  Rovereto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pedrinolla","sequence":"additional","affiliation":[{"name":"Sport, Mountain and Health Research Centre (CeRiSM) University of Verona and University of Trento  Rovereto Italy"},{"name":"Department of Cellular, Computational and Integrative Biology (CIBIO) University of Trento  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2196\/27547"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142143"},{"key":"e_1_2_10_4_1","first-page":"255","volume-title":"The bioengineering of sport","author":"Bondi D.","year":"2023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/TII.2021.3134679"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2025.107928"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"Donavalli S. 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