{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:56:29Z","timestamp":1790877389596,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Circulatory shock remains difficult to manage because fluid resuscitation and catecholamines may exacerbate vascular dysfunction and tissue hypoperfusion. This prospective physiological analysis, embedded within a multicentre phase IV study, examined whether selectively targeting the venous circulation with centhaquine improves circulatory dynamics in spontaneously breathing patients with mixed hypovolaemic\u2013vasodilatory shock (MHVS). Fifteen spontaneously breathing adults with MHVS received centhaquine (0.01\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) in addition to standard care. Over 300\u00a0min, mean circulatory filling pressure analogue increased from 6.03\u00a0\u00b1\u00a00.22 to 7.28\u00a0\u00b1\u00a00.21\u00a0mmHg and driving pressure for venous return from 5.88\u00a0\u00b1\u00a00.22 to 7.16\u00a0\u00b1\u00a00.21\u00a0mmHg (adjusted\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001 for both), while estimated central venous pressure remained near atmospheric pressure and resistance to venous return remained unchanged. Cardiac output increased from 5.62\u00a0\u00b1\u00a00.22 to 6.80\u00a0\u00b1\u00a00.24 L\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    and mean arterial pressure from 56.8\u00a0\u00b1\u00a01.5 to 69.8\u00a0\u00b1\u00a02.0\u00a0mmHg (adjusted\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001 for both). Effective arterial elastance and systemic vascular resistance did not significantly change over time. Patients received 677\u00a0\u00b1\u00a079\u00a0mL of crystalloids during the study period, and no drug\u2010related adverse events were observed. The findings of this preliminary physiological study suggest that selective venoconstriction may augment venous return and systemic haemodynamics in spontaneously breathing patients with MHVS without evidence of major adverse haemodynamic effects.\n                  <\/jats:p>","DOI":"10.1113\/ep093743","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:44:30Z","timestamp":1788255870000},"page":"4421-4434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Haemodynamic effects of selective venoconstriction with centhaquine in spontaneously breathing patients with mixed hypovolaemic\u2010vasodilatory shock"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-4665","authenticated-orcid":false,"given":"Athanasios","family":"Chalkias","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Outcomes Research Consortium  Houston Texas USA"},{"name":"Department of Critical Care Medicine Tzaneio General Hospital  Piraeus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Khanna","sequence":"additional","affiliation":[{"name":"Aman Hospital and Research Centre Organisation  Vadodara Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krish","family":"Vaidya","sequence":"additional","affiliation":[{"name":"I Cure Heart Care Vadodara Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmesh","family":"Shah","sequence":"additional","affiliation":[{"name":"Pharmazz India Pvt. Ltd.  Greater Noida Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Gulati","sequence":"additional","affiliation":[{"name":"Pharmazz Inc., Research and Development  Willowbrook Illinois USA"},{"name":"Department of Bioengineering The University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Midwestern University  Downers Grove Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.04.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3639"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00622.2016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00931.2015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417522"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001742"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44254-025-00119-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-022-01991-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050724"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-022-00440-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063494"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2014.09.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181fa057f"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.6.1676"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2433-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2098-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.060"},{"key":"e_1_2_10_19_1","unstructured":"Gaieski D. 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