{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:04:47Z","timestamp":1790168687071,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Women with a history of gestational diabetes mellitus (GDM) have a greater risk of developing type 2 diabetes mellitus and cardiovascular disease than healthy control (HC) women who had an uncomplicated pregnancy. Microvascular endothelial dysfunction, mediated by reduced nitric oxide (NO)\u2010dependent mechanisms, persists after GDM. However, it is unknown whether cutaneous sensory nerve\u2010mediated dilatation is similarly reduced in these women. We hypothesised that women with a history of GDM would exhibit attenuated sensory nerve\u2010mediated vasodilatation compared with HC women. One intradermal microdialysis fibre was placed in the ventral forearm of 30 HC and 22 GDM women for the local delivery of lactated Ringer's solution during a local heating protocol (42\u00b0C; 0.1\u00b0C\u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). The heater remained at 42\u00b0C until blood flow plateaued (\u223c40\u00a0min). Next, the site was perfused with 15\u00a0mM\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>G<\/jats:sup>\n                    \u2010nitro\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010arginine methyl ester (a NO synthase inhibitor; \u223c40\u00a0min) to determine NO\u2010dependent dilatation. Red blood cell flux was measured by laser\u2010Doppler flowmetry (LDF). Cutaneous vascular conductance was calculated (CVC\u00a0=\u00a0LDF\/mean arterial pressure) and normalized to maximum (28\u00a0mM sodium nitroprusside + local heat 43\u00b0C). The initial sensory nerve\u2010mediated peak response was not different between groups (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.623). The endothelium\u2010dependent plateau (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and NO contribution to the plateau (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) were attenuated in GDM compared with HC women. Our findings suggest that despite reductions in endothelium\u2010 and NO\u2010dependent dilatation, women who had GDM do not exhibit impairments in local cutaneous sensory nerve\u2010mediated vasodilatation compared with HC women.\n                  <\/jats:p>","DOI":"10.1113\/ep093827","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:26:57Z","timestamp":1790166417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Women with a history of gestational diabetes mellitus have preserved sensory nerve\u2010mediated dilatation in the cutaneous microvasculature"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-5097","authenticated-orcid":false,"given":"Grace S.","family":"Maurer","sequence":"first","affiliation":[{"name":"Department of Health, Sport, and Human Physiology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey S.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Health, Sport, and Human Physiology University of Iowa  Iowa City Iowa USA"},{"name":"Carver College of Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana I.","family":"Jalal","sequence":"additional","affiliation":[{"name":"Carver College of Medicine University of Iowa  Iowa City Iowa USA"},{"name":"The Iowa City Veteran Affairs Health Care System  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-3879","authenticated-orcid":false,"given":"Anna E.","family":"Stanhewicz","sequence":"additional","affiliation":[{"name":"Department of Health, Sport, and Human Physiology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus","volume":"131","year":"2018","journal-title":"Obstetrics and Gynecology"},{"issue":"7","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.2337\/diacare.20.7.1154","article-title":"Long\u2010term hyperglycemia is related to peripheral nerve changes at a diabetes duration of 4 years. 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