{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:56:29Z","timestamp":1790877389614,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102019\u201004438"],"award-info":[{"award-number":["RGPIN\u20102019\u201004438"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypoxaemia occurs in intermittent forms, such as obstructive sleep apnoea, and in continuous forms, such as at high altitude, and is increasingly recognized as a modulator of cardiometabolic risk. Although hypoxaemia alters postprandial glucose and lipid metabolism, its effects on ketone bodies remain unclear. Using a randomized crossover design, we examined whether 6\u00a0h of normoxaemia or intermittent hypoxaemia (15 hypoxaemic cycles\/h targeting \u223c85% peripheral oxyhaemoglobin saturation with 100% medical\u2010grade nitrogen) alters plasma \u03b2\u2010hydroxybutyrate (BHB) concentrations in 12 young adult females (mean [SD]: 21 [3] years) following a high\u2010fat meal (33% of estimated daily energy requirements; 59% of energy from fat). In a follow\u2010up session, a subset (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08) completed 6\u00a0h of continuous hypoxaemia (fraction of inspired oxygen \u223c12.0% in a normobaric chamber). Postprandial data were analysed using baseline\u2010adjusted linear mixed\u2010effects models, with Bonferroni post hoc tests. A time \u00d7 condition interaction (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.010) indicated that BHB concentrations at 360\u00a0min were higher during continuous hypoxaemia (0.247\u00a0mmol\/L; 95% CI: 0.218\u20130.275) than normoxaemia (0.176\u00a0mmol\/L; 95% CI: 0.153\u20130.200;\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>Bonferroni<\/jats:sub>\n                    \u00a0=\u00a00.029) and intermittent hypoxaemia (0.163\u00a0mmol\/L; 95% CI: 0.139\u20130.186;\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>Bonferroni<\/jats:sub>\n                    \u00a0=\u00a00.002), representing increases of 13.0% and 14.2% in estimated marginal means, respectively. This response was accompanied by higher postprandial plasma glucose and triglyceride concentrations during continuous hypoxaemia than during normoxaemia and intermittent hypoxaemia (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>Bonferroni<\/jats:sub>\n                    \u2264 0.002), despite similar plasma insulin and non\u2010esterified fatty acid responses across conditions (\n                    <jats:italic>P<\/jats:italic>\n                    \u2265 0.081). These findings indicate that continuous hypoxaemia increases late postprandial plasma BHB concentrations in young adult females.\n                  <\/jats:p>","DOI":"10.1113\/ep093829","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:31:17Z","timestamp":1784928677000},"page":"4303-4314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma \u03b2\u2010hydroxybutyrate concentrations in young adult females after a high\u2010fat meal under normoxaemia, intermittent hypoxaemia and continuous hypoxaemia: An exploratory analysis"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-3174","authenticated-orcid":false,"given":"Nicholas","family":"Goulet","sequence":"first","affiliation":[{"name":"Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexanne","family":"Larocque","sequence":"additional","affiliation":[{"name":"Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Marcoux","sequence":"additional","affiliation":[{"name":"Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0881-373X","authenticated-orcid":false,"given":"Vincent","family":"Bourgon","sequence":"additional","affiliation":[{"name":"Laboratoire du Sommeil, D\u00e9partement de psycho\u00e9ducation et de psychologie Universit\u00e9 du Qu\u00e9bec en Outaouais  Gatineau Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-6235","authenticated-orcid":false,"given":"Jean\u2010Fran\u00e7ois","family":"Mauger","sequence":"additional","affiliation":[{"name":"Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwan","family":"Amaratunga","sequence":"additional","affiliation":[{"name":"Institut du Savoir Montfort Montfort Hospital  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-7740","authenticated-orcid":false,"given":"Pascal","family":"Imbeault","sequence":"additional","affiliation":[{"name":"Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"},{"name":"Institut du Savoir Montfort Montfort 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