{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:06:38Z","timestamp":1785434798660,"version":"3.56.0"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB\/c mice were randomly allocated into four experimental groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX\u201012.5 and DN+SPX\u201025). To induce the diabetic state, subjects received a single intraperitoneal (\n                    <jats:sc>i.p.<\/jats:sc>\n                    ) injection of streptozotocin (STZ) at a dosage of 150\u00a0mg\/kg. Following the establishment of DN, the treatment groups were administered SPX (12.5 or 25\u00a0\u00b5g\/kg\/day) via\n                    <jats:sc>i.p.<\/jats:sc>\n                    injection for 15 consecutive days, whereas the untreated DN group received an equivalent volume of saline vehicle. Thermal hyperalgesia and mechanical allodynia were subsequently evaluated utilizing the hot plate, tail\u2010flick and electronic von Frey behavioural paradigms. in vitro assays demonstrated that SPX administration significantly restored the viability of high glucose\u2010exposed dorsal root ganglion cells, while in vivo assessments revealed a marked attenuation of mechanical allodynia and thermal hyperalgesia in SPX\u2010treated diabetic mice. Furthermore, SPX exhibited profound antioxidant and immunomodulatory properties by mitigating systemic oxidative stress and pro\u2010inflammatory cytokine responses, concomitantly preserving the structural integrity of the pancreatic islets. Taken together, these findings provide compelling evidence that SPX confers neuroprotective benefits in STZ\u2010induced DN through the modulation of oxidative stress, neuroinflammation and nociceptive sensitization, thereby highlighting its potential as a novel therapeutic agent for diabetic microvascular complications.\n                  <\/jats:p>","DOI":"10.1113\/ep093879","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:44:46Z","timestamp":1780980286000},"page":"3800-3817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models"],"prefix":"10.1113","volume":"111","author":[{"given":"Mehmet Refik","family":"Bahar","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetic, Faculty of Health Science Osmaniye Korkut Ata University  Osmaniye Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seval Ulku","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine Izmir Bak\u0131rcay University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cigdem","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Home Patient Care, School of Health Services Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Taslidere","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-4880","authenticated-orcid":false,"given":"Mete","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine Firat University  Elazig 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