{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:30:21Z","timestamp":1787121021616,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute mountain sickness (AMS) is common after ascent to altitude, yet individual susceptibility remains difficult to predict and diagnosis relies on subjective report. Sleep disturbances and nocturnal hypoxaemia at altitude may provide insight, but their relationship to AMS is incompletely understood. In a sub\u2010study of a randomized, placebo\u2010controlled trial, 112 healthy, lowland\u2010dwelling volunteers rapidly ascended to 3810\u00a0m. AMS was assessed using the 2018 Lake Louise Scoring System (LLSS); sleep scores were recorded separately. Overnight monitoring used the WatchPAT300 device to measure oxygen saturation, oxygen desaturation index, respiratory disturbance index, apnoea\u2013hypopnoea index and inferred sleep stage. Thirty\u2010eight participants (34%) developed AMS by the 2018 LLSS criteria. Compared with unaffected individuals, those with AMS had lower mean nocturnal , greater cumulative time with \u00a0&lt;\u00a070%, and higher oxygen desaturation index and respiratory disturbance index on nights 2 and 3. Respiratory disturbance indices improved only in participants without AMS, while AMS\u2010positive subjects demonstrated persistent reductions in estimated deep sleep, and higher self\u2010reported sleep disturbance scores. A sensitivity analysis applying 1993 LLSS criteria identified 64 subjects (58%) with AMS, and strengthened between\u2010group differences in nocturnal , but not respiratory indices. In exploratory multivariable analysis, cumulative time with\n                    <jats:sub>\u00a0<\/jats:sub>\n                    &lt;\u00a070% and first\u2010night sleep disturbance score at altitude remained independently associated with AMS. In summary, nocturnal hypoxaemia was associated with AMS status under both 2018 and 1993 criteria, while failure of respiratory index normalization and impaired sleep architecture are associated with AMS persistence, suggesting a longitudinal signal of failed acclimatization. These findings support further examination of sleep\u2010related metrics in relation to AMS assessment.\n                  <\/jats:p>","DOI":"10.1113\/ep093915","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:13:02Z","timestamp":1787119982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The contributions of nocturnal hypoxaemia and sleep disturbances to acute mountain sickness"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-3682","authenticated-orcid":false,"given":"D. M.","family":"Williamson","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Gudelunas","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Sall","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1389-9457(03)00111-4","article-title":"Assessment of a wrist\u2010worn device in the detection of obstructive sleep apnea","volume":"4","author":"Ayas N.","year":"2003","journal-title":"Sleep Medicine"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1378\/chest.123.3.695","article-title":"Evaluation of a portable device based on peripheral arterial tone for unattended home sleep studies","volume":"123","author":"Bar A.","year":"2003","journal-title":"Chest"},{"issue":"4","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1440-1843.2004.00625.x","article-title":"Acute mountain sickness is associated with sleep desaturation at high altitude","volume":"9","author":"Burgess K. 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D.","year":"2023","journal-title":"Frontiers in Sleep"},{"issue":"6","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/jtm.12160","article-title":"Serious altitude illness in travelers who visited a pre\u2010travel clinic","volume":"21","author":"Croughs M.","year":"2014","journal-title":"Journal of Travel Medicine"},{"issue":"2","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1183\/09031936.04.00006504","article-title":"Acute mountain sickness is related to nocturnal hypoxemia but not to hypoventilation","volume":"24","author":"Erba P.","year":"2004","journal-title":"European Respiratory Journal"},{"issue":"3","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15175","article-title":"Acute mountain sickness and sleep disturbances differentially influence cognition and mood during rapid ascent to 3000 and 4050 m","volume":"10","author":"Figueiredo P. 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Factor structure and internal consistency of the Lake Louise Score Questionnaire","volume":"14","author":"MacInnis M. 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