{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:52:25Z","timestamp":1791233545849,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Abortion aetiology is critically linked to increased myometrial contractions and maternal psychological stress. Given the limited efficacy of current therapies such as progesterone, investigating novel therapeutic interventions is essential. Melatonin exerts reproductive benefits. Agomelatine stands out as an agent that exerts antidepressant effects through serotonin receptor (5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    ) antagonism in addition to its potent melatonergic activity. Furthermore, agomelatine inhibits myometrial contractions. In this context, this study investigates agomelatine's therapeutic potential in an abortion model across behavioural, biochemical and histological parameters. Eighty female Sprague\u2013Dawley rats were randomized into eight groups: control, sham, abortion, melatonin (M), agomelatine (A), progesterone (P) and combinations (MP, AP). Following pregnancy (Day 0), oral treatments were administered daily for 14\u00a0days. Abortion was induced via mifepristone on Day 11. Depressive\u2010like behaviours were assessed using a forced swimming test on Day 13. The next day, rats were sacrificed for serum hormone analysis and uterine histological evaluation. The forced swimming test showed shorter immobility time in the AP group compared to the abortion group. An enzyme\u2010linked immunosorbent Assay revealed lower serum prostaglandin F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    level in the AP group and lower serum oxytocin levels in the M, A, MP and AP groups versus the abortion group. Histologically, M, A, P, MP and AP groups exhibited higher scores for complete fetus, decidual congestion, decidual inflammation and cytotrophoblast\u2013syncytiotrophoblast cells compared to the abortion group. Additionally, the abortion group showed higher decidual necrosis than controls. In conclusion, agomelatine\u2010containing protocols demonstrated restorative effects in abortion across behavioural, biochemical and histological parameters. These effects of agomelatine provide a new perspective on the currently limited options for treatment of abortion.\n                  <\/jats:p>","DOI":"10.1113\/ep093951","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:56:21Z","timestamp":1791230181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Agomelatine ameliorates abortion\u2010related alterations in rats: Insights from behavioural, biochemical and histological analyses"],"prefix":"10.1113","author":[{"given":"Mehtap","family":"Pervin","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Dila","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Sait","family":"Bozyil","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Sayin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husna","family":"Batmaz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-3672","authenticated-orcid":false,"given":"Serhat","family":"Hancer","sequence":"additional","affiliation":[{"name":"Department of Histology &amp; Embryology Gaziantep City Hospital  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih Burcin","family":"Kavak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"Kocaman","sequence":"additional","affiliation":[{"name":"Department of Histology &amp; Embryology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Kelestimur","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Istanbul Okan University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1585-7248","authenticated-orcid":false,"given":"Emine","family":"Kacar","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.3390\/cimb45080407","article-title":"Forced swimming\u2010induced depressive\u2010like behavior and anxiety are reduced by Chlorpheniramine via suppression of oxidative and inflammatory mediators and activating the Nrf2\u2010BDNF signaling pathway","volume":"45","author":"Alamri H. S.","year":"2023","journal-title":"Current Issues in Molecular Biology"},{"issue":"2","key":"e_1_2_10_3_1","article-title":"Bed rest during pregnancy for preventing miscarriage","volume":"2005","author":"Aleman A.","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3390\/biomedicines11082112","article-title":"Effect of vitamin D3 on depressive behaviors of rats exposed to chronic unpredictable mild stress","volume":"11","author":"Al\u2010Ramadhan F. R.","year":"2023","journal-title":"Biomedicines"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114743","article-title":"Cardioprotective effects of melatonin and metformin against doxorubicin\u2010induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics","volume":"192","author":"Arinno A.","year":"2021","journal-title":"Biochemical Pharmacology"},{"issue":"3","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/aji.12473","article-title":"Progesterone\u2010regulated endometrial factors controlling implantation","volume":"75","author":"Bhurke A. S.","year":"2016","journal-title":"American Journal of Reproductive Immunology"},{"issue":"2","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1139\/jpn.0414","article-title":"Antidepressant\u2010like activity of S 20098 (agomelatine) in the forced swimming test in rodents: Involvement of melatonin and serotonin receptors","volume":"29","author":"Bourin M.","year":"2004","journal-title":"Journal of Psychiatry & Neuroscience: JPN"},{"issue":"1997","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1098\/rspb.2023.0191","article-title":"The human placenta: New perspectives on its formation and function during early pregnancy","volume":"290","author":"Burton G. J.","year":"2023","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"issue":"1","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-38025-9","article-title":"Progesterone\u2010mediated reversal of mifepristone\u2010induced pregnancy termination in a rat model: An exploratory investigation","volume":"13","author":"Camilleri C.","year":"2023","journal-title":"Scientific Reports"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2015.11.054","article-title":"Studies on the reproductive effects of chronic treatment with agomelatine in the rat","volume":"770","author":"Canpolat S.","year":"2016","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/ijms21010300","article-title":"Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms","volume":"21","author":"Chuffa L. G.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2015.10.005","article-title":"The endocrine function of human placenta: An overview","volume":"32","author":"Costa M. A.","year":"2016","journal-title":"Reproductive BioMedicine Online"},{"issue":"2","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/REP-21-0159","article-title":"Melatonin\u2010MT1 signal is essential for endometrial decidualization","volume":"162","author":"Cui L.","year":"2021","journal-title":"Reproduction"},{"key":"e_1_2_10_14_1","volume-title":"Williams obstetrics","author":"Cunningham F. G.","year":"2022"},{"issue":"1","key":"e_1_2_10_15_1","first-page":"9","article-title":"The prevent miscarriage effects of Yun Kang oral liquid on threatened abortion rat induced by kidney deficiency and luteum inhibition","volume":"35","author":"Dai M. Z.","year":"2019","journal-title":"Chinese Journal of Applied Physiology"},{"issue":"1","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/JME-19-0212","article-title":"90 YEARS OF PROGESTERONE: New insights into progesterone receptor signaling in the endometrium required for embryo implantation","volume":"65","author":"DeMayo F. J.","year":"2020","journal-title":"Journal of Molecular Endocrinology"},{"issue":"12","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"18083","DOI":"10.1007\/s00210-025-04409-z","article-title":"Effect of vitamin D and location of asprosin, spexin and meteorin\u2010like antibodies in the liver of rats with isoproterenol\u2010induced myocardial infarction","volume":"398","author":"Erdo\u011fan M. M.","year":"2025","journal-title":"Naunyn\u2010Schmiedeberg's Archives of Pharmacology"},{"issue":"4","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jsbmb.2004.05.001","article-title":"Biosynthesis and catabolism of prostaglandin F2(alpha) (PGF2\u03b1) are controlled by progesterone in the rat uterus during pregnancy","volume":"91","author":"Farina M.","year":"2004","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"3","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2174\/157015910792246227","article-title":"A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation","volume":"8","author":"Fornaro M.","year":"2010","journal-title":"Current Neuropharmacology"},{"issue":"1","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/s41598-025-85826-1","article-title":"Pharmacovigilance study of the association between progestogen and depression based on the FDA adverse event reporting System (FAERS)","volume":"15","author":"Gao H.","year":"2025","journal-title":"Scientific Reports"},{"issue":"4","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1113\/EP088254","article-title":"Melissa officinalis L. hydro\u2010alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis","volume":"105","author":"Ghazizadeh J.","year":"2020","journal-title":"Experimental Physiology"},{"issue":"3","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cell.2013.12.025","article-title":"Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation","volume":"156","author":"Goddard L. M.","year":"2014","journal-title":"Cell"},{"issue":"4","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2826.2008.01661.x","article-title":"Pregnancy\u2010induced adaptation in the neuroendocrine control of prolactin secretion","volume":"20","author":"Grattan D. R.","year":"2008","journal-title":"Journal of Neuroendocrinology"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jad.2021.10.026","article-title":"The mental health impact of perinatal loss: A systematic review and meta\u2010analysis","volume":"297","author":"Herbert D.","year":"2022","journal-title":"Journal of Affective Disorders"},{"issue":"5","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.5603\/EP.a2016.0035","article-title":"Rola b\u0142onowych receptor\u00f3w melatoniny w zale\u017cnym od melatoniny uwalnianiu oksytocyny z uk\u0142adu podwzg\u00f3rze\u2010cz\u0119\u015b\u0107 nerwowa przysadki szczura\u2014Badania in vitro oraz in vivo","volume":"67","author":"Juszczak M.","year":"2016","journal-title":"Endokrynologia Polska"},{"issue":"6","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.33549\/physiolres.935064","article-title":"Modulation of melatonin receptors regulates reproductive physiology: The impact of agomelatine on the estrus cycle, gestation, offspring, and uterine contractions in rats","volume":"72","author":"Kacar E.","year":"2023","journal-title":"Physiological Research"},{"issue":"6","key":"e_1_2_10_27_1","first-page":"479","article-title":"Agomelatine in the treatment of major depressive disorder: Potential for clinical effectiveness","volume":"24","author":"Kennedy S. H.","year":"2010","journal-title":"Central Nervous System Drugs"},{"key":"e_1_2_10_28_1","article-title":"Agomelatine inhibits spontaneous and prostaglandin F2 alpha induced contractions of rat myometrium through mechanisms interacting both extracellular and intracellular calcium signaling","volume":"34","author":"Kutlu S.","year":"2015","journal-title":"Proceedings of the Physiological Society"},{"issue":"3","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00213-011-2597-5","article-title":"Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC","volume":"221","author":"Ladurelle N.","year":"2012","journal-title":"Psychopharmacology"},{"issue":"1","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2013.07.010","article-title":"Melatonin: The watchdog of villous trophoblast homeostasis against hypoxia\/reoxygenation\u2010induced oxidative stress and apoptosis","volume":"381","author":"Lanoix D.","year":"2013","journal-title":"Molecular and Cellular Endocrinology"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.placenta.2020.12.012","article-title":"PGE2 vs PGF2\u03b1 in human parturition","volume":"104","author":"Li W.","year":"2021","journal-title":"Placenta"},{"issue":"2","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.xfss.2020.10.004","article-title":"Aberrant expression of oxytocin receptor in endometrium and decidua in women who have experienced recurrent implantation failure","volume":"1","author":"Liu C.","year":"2020","journal-title":"F&S Science"},{"issue":"4","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1080\/14647273.2021.1871783","article-title":"Patterns of sex hormone receptor expression in stimulated endometrium from oocyte donors","volume":"25","author":"Manvelyan E.","year":"2022","journal-title":"Human Fertility"},{"issue":"4","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: Some helpful considerations","volume":"62","author":"Marcondes F. K.","year":"2002","journal-title":"Brazilian Journal of Biology"},{"issue":"3","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/jpet.103.051797","article-title":"The novel melatonin agonist agomelatine (S20098) is an antagonist at 5\u2010Hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways","volume":"306","author":"Millan M. J.","year":"2003","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12619","article-title":"Inflammatory responses in early pregnancy: Physiological and pathological perspectives","volume":"23","author":"Negishi Y.","year":"2024","journal-title":"Reproductive Medicine and Biology"},{"issue":"19","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the survival of early pregnancy","volume":"345","author":"Norwitz E. R.","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/s41598-017-01792-3","article-title":"The association between psychological stress and miscarriage: A systematic review and meta\u2010analysis","volume":"7","author":"Qu F.","year":"2017","journal-title":"Scientific Reports"},{"issue":"10285","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: The epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby S.","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2023.107233","article-title":"Behavioral and electrophysiological (ECoG) effects of haplophyllum robustum and TRPA1 antagonist in adult male wistar rats","volume":"233","author":"Rahati Quchani M.","year":"2023","journal-title":"Toxicon"},{"issue":"6","key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.31083\/j.fbl2806122","article-title":"Melatonin receptor 1B and corticosteroid receptor polymorphisms in infertile women with implantation failure and miscarriages","volume":"28","author":"Robeva R.","year":"2023","journal-title":"Frontiers in Bioscience (Landmark Edition)"},{"issue":"6","key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/09513590902730812","article-title":"Impact of first trimester and postpartum period thyroid autoantibodies on abortus incidence in Turkish pregnant women","volume":"25","author":"Sezer K.","year":"2009","journal-title":"Gynecological Endocrinology"},{"issue":"7458","key":"e_1_2_10_43_1","first-page":"152","article-title":"Threatened miscarriage: Evaluation and management","volume":"329","author":"Sotiriadis A.","year":"2004","journal-title":"British Medical Journal (Clinical Research ed.)"},{"issue":"3","key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1176\/appi.neuropsych.11090216","article-title":"Agomelatine in depressive disorders: Its novel mechanisms of action","volume":"24","author":"Srinivasan V.","year":"2012","journal-title":"Journal of Neuropsychiatry and Clinical Neurosciences"},{"issue":"4","key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.4103\/1673-5374.353479","article-title":"Agomelatine: A potential novel approach for the treatment of memory disorder in neurodegenerative disease","volume":"18","author":"Su Q.","year":"2023","journal-title":"Neural Regeneration Research"},{"issue":"3","key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/ijms21031135","article-title":"Importance of melatonin in assisted reproductive technology and ovarian aging","volume":"21","author":"Tamura H.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.reprotox.2008.03.005","article-title":"Melatonin and pregnancy in the human","volume":"25","author":"Tamura H.","year":"2008","journal-title":"Reproductive Toxicology"},{"issue":"1","key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/FM9.0000000000000135","article-title":"Decidualization and related pregnancy complications","volume":"4","author":"Tong J.","year":"2022","journal-title":"Maternal\u2010Fetal Medicine"},{"issue":"12","key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.3390\/biomedicines10123252","article-title":"The role of melatonin in pregnancy and the health benefits for the newborn","volume":"10","author":"Verteramo R.","year":"2022","journal-title":"Biomedicines"},{"issue":"4","key":"e_1_2_10_50_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124001","article-title":"Single administration of ultra\u2010low\u2010dose lipopolysaccharide in rat early pregnancy induces tlr4 activation in the placenta contributing to preeclampsia","volume":"10","author":"Xue P.","year":"2015","journal-title":"PLoS ONE"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal\u2010fetal interface","volume":"10","author":"Yang F.","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12958-017-0297-7","article-title":"Effects of melatonin administration on embryo implantation and offspring growth in mice under different schedules of photoperiodic exposure","volume":"15","author":"Zhang L.","year":"2017","journal-title":"Reproductive Biology and Endocrinology"},{"issue":"6","key":"e_1_2_10_53_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.apjtm.2016.04.002","article-title":"Study on prevention effect of Zishen Yutai pill combined with progesterone for threatened abortion in rats","volume":"9","author":"Zhang Y.","year":"2016","journal-title":"Asian Pacific Journal of Tropical Medicine"},{"issue":"2","key":"e_1_2_10_54_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3390\/ijms25020733","article-title":"Melatonin alleviates lipopolysaccharide\u2010induced abnormal pregnancy through MTNR1B regulation of m6A","volume":"25","author":"Zhao S.","year":"2024","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP093951","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:56:31Z","timestamp":1791230191000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP093951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":53,"alternative-id":["10.1113\/EP093951"],"URL":"https:\/\/doi.org\/10.1113\/ep093951","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"EP093951"}}