{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:19:42Z","timestamp":1788013182275,"version":"build-2784847793"},"reference-count":74,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1250240"],"award-info":[{"award-number":["1250240"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The two\u2010kidney, one\u2010clip (2K1C) model produces renovascular hypertension. The effects on the clipped kidney (CK) are well described, while the non\u2010clipped kidney (NCK) is used as a model to evaluate the effects of high blood pressure. Although most of these effects have been described at later stages of 2K1C hypertension, it remains unclear whether immune antigen\u2010presenting cells (APCs) expand early in the NCK during the first stages of 2K1C hypertension. Our objective was to determine whether the 2K1C model increases the presence and\/or distribution of APCs in the NCK during the early phase of renovascular hypertension. Male C57BL\/6J mice underwent sham surgery or 2K1C surgery (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06). Blood pressure was assessed, and NCKs were collected on day 7. Global expression of major histocompatibility complex (MHC)\u2010II (APC marker) and F4\/80 (monocyte\/macrophage lineage) was quantified by immunoblotting, while spatial distribution was evaluated by immunohistochemistry (IHC) and morphological analysis. 2K1C produced a significant increase in blood pressure in the NCK without albuminuria. Immunoblot experiments showed no significant differences in global MHC\u2010II or F4\/80 levels between sham and 2K1C groups in the NCK. However, IHC revealed a focal increase in F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    signal and a significant rise in F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    area fraction, consistent with localized monocytic\/macrophage enrichment not captured by whole\u2010tissue homogenates from NCK. By contrast, F4\/80 immunostaining was observed in conspicuous resident cells. After 7\u00a0days of 2K1C hypertension, contralateral renal APC expansion is not evident at the global protein level, yet focal F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    enrichment suggests early regional and focal immune remodelling that may precede later overt inflammation.\n                  <\/jats:p>","DOI":"10.1113\/ep093957","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:04:01Z","timestamp":1788012241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early\u2010stage 2K1C renovascular hypertension does not increase global MHC\u2010II or F4\/80 abundance in the non\u2010clipped kidney but reveals focal F4\/80\n                    <sup>+<\/sup>\n                    induction"],"prefix":"10.1113","author":[{"given":"Pilar","family":"C\u00e1rdenas","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison C.","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Castillo\u2010Geraldo","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Cid\u2010Salinas","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera","family":"Saez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Universidad San Sebasti\u00e1n  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanny","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Universidad San Sebasti\u00e1n  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Reyes","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Universidad San Sebasti\u00e1n  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Rosenkoetter","sequence":"additional","affiliation":[{"name":"Section of Cardio\u2010Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suarybell Guzm\u00e1n","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Section of Cardio\u2010Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"De Miguel","sequence":"additional","affiliation":[{"name":"Section of Cardio\u2010Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-6811","authenticated-orcid":false,"given":"Cristi\u00e1n A.","family":"Amador","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Universidad San Sebasti\u00e1n  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-1448","authenticated-orcid":false,"given":"Alexis A","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"},{"name":"Centro de Investigaci\u00f3n Interdisciplinaria en Biomedicina, Biotecnolog\u00eda y Bienestar (CID3B) Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1089\/jir.2010.0043","article-title":"Angiotensin II type\u20102 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNF alpha production","volume":"31","author":"Abadir P. 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M.","year":"2019","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41392-025-02124-y","article-title":"Tissue macrophages: Origin, heterogenity, biological functions, diseases and therapeutic targets","volume":"10","author":"Guan F.","year":"2025","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"5","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ndt\/12.5.899","article-title":"Leukocyte infiltration and ICAM\u20101 expression in two\u2010kidney one\u2010clip hypertension","volume":"12","author":"Haller H.","year":"1997","journal-title":"Nephrology, Dialysis, Transplantation"},{"issue":"4","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/HYPERTENSIONAHA.117.10145","article-title":"Myeloid CD11c+ antigen\u2010presenting cells ablation prevents hypertension in response to angiotensin II plus high\u2010salt diet","volume":"71","author":"Hevia D.","year":"2018","journal-title":"Hypertension"},{"issue":"3","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00424-017-1950-x","article-title":"The role of macrophages in hypertension and its complications","volume":"469","author":"Justin Rucker A.","year":"2017","journal-title":"Pflugers Archiv: European Journal of Physiology"},{"issue":"7","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41581-020-0272-y","article-title":"Kidney dendritic cells: Fundamental biology and functional roles in health and disease","volume":"16","author":"Kurts C.","year":"2020","journal-title":"Nature Reviews Nephrology"},{"key":"e_1_2_10_32_1","first-page":"349","article-title":"Vascular unresponsiveness to thromboxane A(2) (TXA(2)) is associated with a polymorphism at the thromboxane (TP) receptor gene locus","volume":"34","author":"Le T. 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N.","year":"2011","journal-title":"American Journal of Physiology\u2010Renal Physiology"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1642525","article-title":"The multifaceted role of macrophages in kidney physiology and diseases","volume":"16","author":"Ma Y.","year":"2025","journal-title":"Frontiers in Immunology"},{"issue":"5","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ki.1985.73","article-title":"Pressure dependence of exaggerated natriuresis in two\u2010kidney, one clip Goldblatt hypertensive rats","volume":"27","author":"Mackenzie H. S.","year":"1985","journal-title":"Kidney International"},{"issue":"3","key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physiolgenomics.00063.2010","article-title":"Gene expression profiles linked to AT(1) angiotensin receptors in the kidney","volume":"42","author":"Makhanova N. 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