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Interhemispheric inhibition (IHI) is one approach to probe transcallosal communication using transcranial magnetic stimulation (TMS) whereby the motor evoked potential (MEP) elicited by TMS is reduced in amplitude when preceded by a conditioning TMS pulse delivered to the opposite M1. In a double\u2010blinded, placebo\u2010controlled study, 24 participants received 2.5\u00a0mg of lorazepam (GABA\n                    <jats:sub>A<\/jats:sub>\n                    agonist), 50\u00a0mg of baclofen (GABA\n                    <jats:sub>B<\/jats:sub>\n                    agonist) and a placebo in separate sessions. Short\u2010interval interhemispheric inhibition (SIHI) and long\u2010interval interhemispheric inhibition (LIHI) recorded from the first dorsal interosseous muscle were quantified before and at peak plasma concentration following drug ingestion. Baclofen significantly reduced SIHI and LIHI while lorazepam had no effect. These findings advance our understanding of the pharmacological basis of transcallosal inhibition in humans.\n                  <\/jats:p>","DOI":"10.1113\/ep093963","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:59:56Z","timestamp":1782431996000},"page":"3818-3827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of baclofen and lorazepam on interhemispheric inhibition in humans"],"prefix":"10.1113","volume":"111","author":[{"given":"Faith C.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Kinesiology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma R.","family":"Ramdeo","sequence":"additional","affiliation":[{"name":"Department of Kinesiology McMaster University  Hamilton Ontario 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