{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:58:07Z","timestamp":1790877487045,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00070\/2020"],"award-info":[{"award-number":["UIDB\/00070\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00070\/2020"],"award-info":[{"award-number":["UIDP\/00070\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The association between higher levels of physical activity and lower cancer risk and mortality is well established. However, a causal link is yet to be proven. Recent studies showed a decrease in the proliferation rates of cultured human cancer cells when the human serum used to stimulate them was conditioned by acute exercise. Here, we tested the hypothesis that serum mediates some of the putative benefits of exercise on cancer through alterations to the growth pattern and susceptibility to chemotherapy agents of cancer cells. To this end, human non\u2010small cell lung cancer cells were exposed to serum, collected before or after an acute exercise intervention, from two cohorts that differed significantly in their levels of physical activity and, accordingly, cardiorespiratory fitness, but were otherwise identical (non\u2010exercisers and master athletes). Serum levels of glucose, lipids, albumin, C\u2010reactive protein and cytokines were determined, and the impact of the serum responses to acute and lifelong exercise on cancer cell growth pattern and susceptibility to cisplatin were analysed. We found that acute exercise decreased the proliferation rate of the cells, yet shortened the lag phase of the cells after detachment, whereas lifelong exercise had the opposite effects. Significantly, we showed, for the first time, that lifelong exercise increased susceptibility to a chemotherapy agent, which might contribute to the decreased cancer mortality rates found among those cancer patients who exercise regularly. Similar to the cellular effects, changes to serum cytokine levels (several of them linked to the senescence\u2010associated secretory phenotype) depended on whether serum was conditioned by acute exercise or by lifelong exercise.<\/jats:p>","DOI":"10.1113\/ep093973","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:29:50Z","timestamp":1784989790000},"page":"4688-4704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute and lifelong exercise modulate the tumorigenic potential of human lung cancer cells and their susceptibility to cisplatin"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1887-8845","authenticated-orcid":false,"given":"Carlos M.","family":"Soares","sequence":"first","affiliation":[{"name":"CIPER, Faculty of Sport Sciences and Physical Education University of Coimbra  Coimbra Portugal"},{"name":"Molecular Physical Chemistry R&amp;D Unit (QFM\u2010UC) University of Coimbra  Coimbra Portugal"},{"name":"CI\u2010ISCE Higher Institute of Educational Sciences of the Douro  Penafiel Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P.","family":"Moura","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo M. R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Immunology Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Hollings Cancer Center Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"CIPER, Faculty of Sport Sciences and Physical Education University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Filipe","sequence":"additional","affiliation":[{"name":"University Hospitals of Coimbra University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Rama","sequence":"additional","affiliation":[{"name":"CIPER, Faculty of Sport Sciences and Physical Education University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"CIPER, Faculty of Sport Sciences and Physical Education University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5197-1697","authenticated-orcid":false,"given":"Ana M.","family":"Urbano","sequence":"additional","affiliation":[{"name":"Molecular Physical Chemistry R&amp;D Unit (QFM\u2010UC) University of Coimbra  Coimbra Portugal"},{"name":"Department of Life Sciences University of Coimbra  Coimbra Portugal"},{"name":"LAQV\/Requimte, Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO) University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1343952"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.R200007-MCP200"},{"key":"e_1_2_11_4_1","volume-title":"Work tests with the bicycle ergometer","author":"\u00c5strand P.\u2010O.","year":"1964"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02388-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10251"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2024-108671"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003848"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.10.030"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12700"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00461.2020"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"issue":"6","key":"e_1_2_11_15_1","first-page":"798","article-title":"Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer","volume":"4","author":"Caan B. 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