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The underlying mechanisms are not fully understood, and a potential contributing factor that has not previously been investigated is alveolar\u2013capillary membrane breaching with extravasation of fluid into the lungs. Sixteen individuals with COPD and 16 age\u2010 and sex\u2010matched healthy controls were included. Alveolar\u2013capillary membrane permeability was quantified using the pulmonary clearance index (PCI), calculated from scintigraphically determined alveolar clearance of\n                    <jats:sup>99m<\/jats:sup>\n                    Tc\u2010labelled diethylenetriaminepentaacetic acid at rest and following an acute exercise bout performed at maximal exertion, as determined by a prior cardiopulmonary exercise test. In addition, lung tissue mass (LTM) was assessed using low\u2010dose computed tomography, with rest\u2010to\u2010post\u2010exercise changes interpreted as reflecting alterations in interstitial fluid accumulation. The mean change in PCI from rest\u2010to\u2010post\u2010exercise was \u22120.01 [95% CI: \u22120.09, 0.06]%\/min in the COPD group and \u22120.05 [95% CI: \u22120.12, 0.02]%\/min in the healthy control group (Group \u00d7 Time interaction,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.446). The mean change in LTM from rest\u2010to\u2010post\u2010exercise was 16.5 [95% CI: \u22127.0, 40.0]g\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    in the COPD group and 35.2 [95% CI: 11.7, 58.7]g\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    in the healthy control group (Group \u00d7 Time interaction,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.258). In conclusion, the present study found no evidence of alveolar\u2013capillary membrane breaching following maximal exercise, neither in individuals with COPD nor in healthy matched controls.\n                  <\/jats:p>","DOI":"10.1113\/ep094018","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:30:10Z","timestamp":1788514210000},"page":"4315-4327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of an acute exercise bout on alveolar\u2013capillary membrane permeability and interstitial fluid accumulation in COPD"],"prefix":"10.1113","volume":"111","author":[{"given":"Rie Skovly","family":"Thomsen","sequence":"first","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-0308","authenticated-orcid":false,"given":"Iben Elmerdahl","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-5032","authenticated-orcid":false,"given":"Stine Buus","family":"Nymand","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Agnes","family":"Lytzen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Peter","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Cellular and Molecular Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-0722","authenticated-orcid":false,"given":"Malte Lund","family":"Adamsen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"COPEACT \u2013 Copenhagen Research Centre for Autoimmune Connective Tissue Disease Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Hanel","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jann","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Medicine The National Hospital  Torshavn Faroe Islands"},{"name":"Faculty of Health Sciences University of the Faroe Islands  Torshavn Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-9506","authenticated-orcid":false,"given":"Ronan M. 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