{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:57:30Z","timestamp":1790877450108,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011576","name":"In\u00f6n\u00fc \u00dcniversitesi","doi-asserted-by":"publisher","award":["TYL\u20102019\u20101930"],"award-info":[{"award-number":["TYL\u20102019\u20101930"]}],"id":[{"id":"10.13039\/501100011576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigated\n                    <jats:italic>Prangos ferulacea<\/jats:italic>\n                    (PF)\u2010induced hepatotoxicity, its potential association with endoplasmic reticulum (ER) stress and proinflammatory cytokines, and the effect of the cannabinoid type 2 receptor agonist JWH\u2010133. Rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a037) were divided into four groups: control\u2013sham group (CSG,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a09), PF extract group (PG,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a09), PF extract + JWH\u2010133 group (PJG,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a09) and JWH\u2010133 group (JG,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010). Hepatic ER stress markers (CHOP, GRP78 and ATF4), interleukin (IL)\u201017, IL\u201023, heat shock protein 72 (HSP72), and calpain, as well as serum IL\u201017, IL\u201023, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein and albumin, were assessed. Liver histology was evaluated using haematoxylin\u2013eosin staining, and apoptosis was assessed by caspase\u20103 immunohistochemistry. No significant between\u2010group differences were observed in hepatic GRP78, CHOP, ATF4, IL\u201017 or IL\u201023 levels. Similarly, serum IL\u201017 and IL\u201023 levels did not differ significantly among the groups. Calpain levels differed significantly among the groups (\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0017), with higher levels in PG (\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0325) and PJG (\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0076) than in CSG. Compared with CSG, PG and PJG showed lower ALT (\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0021 for both), AST (\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0021 for both), albumin (\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0031 and\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0016, respectively) and total protein (\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0056 and\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.0017, respectively) levels. Histopathological damage was significantly greater in PG than in CSG, PJG and JG (all\n                    <jats:italic>P &lt;<\/jats:italic>\n                    \u00a00.0001). Caspase\u20103 immunoreactivity was intense in PG and limited in PJG. PF extract caused marked liver injury without clear canonical ER stress activation. JWH\u2010133 attenuated histopathological damage, consistent with the potential role of CB2 receptor activation. These findings support ER stress\u2010independent mechanisms and warrant further investigation of CB2 activation as a hepatoprotective strategy.\n                  <\/jats:p>","DOI":"10.1113\/ep094039","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:00:56Z","timestamp":1789225256000},"page":"4565-4577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective effect of cannabinoid type 2 receptor agonist (JWH\u2010133) against hepatotoxicity induced by\n                    <i>Prangos ferulacea<\/i>\n                    Lindl. extract"],"prefix":"10.1113","volume":"111","author":[{"given":"Mesut","family":"\u00c7elik","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine Inonu University  Malatya Turkey"},{"name":"Elderly Care Program, Vocational School of Health Services Bing\u00f6l University  Bing\u00f6l Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"\u00c7etin Ta\u015fl\u0131dere","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynal Mete","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-2150","authenticated-orcid":false,"given":"Halil","family":"D\u00fczova","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim Halil","family":"Ge\u00e7ibesler","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety School of Health Sciences Bingol University  Bing\u00f6l Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R\u0131za","family":"\u00c7ali\u015fkan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7a\u011fatay","family":"Ta\u015fkapan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry School of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbranur","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Inonu University  Malatya Turkey"},{"name":"Medical Laboratory Techniques Program Vocational School of Health Services Malatya Turgut Ozal University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32562"},{"key":"e_1_2_10_3_1","first-page":"83","article-title":"Hepatic and renal function in applicators and farmers exposed to organophosphate pesticides in southwest Nigeria","volume":"2","author":"Arinola O.","year":"2014","journal-title":"Archives of Basic and Applied Medicine"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(15)30159-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-007-0057-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02155.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091248"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7451com"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707584"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.11.058"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1991.52.12.1969"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401940"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2019.12"},{"key":"e_1_2_10_14_1","first-page":"2","article-title":"The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin\u2010induced pain in mice","volume":"9","author":"Emamghoreishi M.","year":"2012","journal-title":"Journal of Jahrom University of Medical Sciences"},{"key":"e_1_2_10_15_1","first-page":"179","article-title":"Hydro\u2010alcoholic extract of the root of Prangos ferulacea (L.) 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