{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:54:40Z","timestamp":1790952880008,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","award":["TSA\u20102023\u201020451"],"award-info":[{"award-number":["TSA\u20102023\u201020451"]}],"id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sedentary behaviour is increasingly recognized as a risk factor for systemic disorders; however, its effects on male reproductive health and penile tissue integrity remain insufficiently understood. Furthermore, the therapeutic role of whole\u2010body vibration (WBV) has not been investigated. This study evaluated the effects of sedentary behaviour on testicular and penile tissues and examined whether WBV could attenuate these alterations. We hypothesized that sedentary behaviour would impair spermatogenesis and penile tissue integrity, whereas WBV would attenuate these effects. Thirty\u2010two male Wistar rats were randomized into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08\/group): Control, Sedentary, Sedentary+WBV and WBV. Sedentary conditions were induced for 28\u00a0days via a reduced\u2010cage model, with daily WBV application (45\u00a0Hz, 3\u00a0mm). Serum testosterone, sperm parameters, testicular histology and penile smooth muscle\u2010to\u2010collagen ratio were assessed. Sedentary behaviour impaired spermatogenesis, with lower Johnsen scores (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.008), reduced sperm concentration (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.006) and motility (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001), and increased morphological abnormalities (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001). It also reduced the penile smooth muscle\u2010to\u2010collagen ratio (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001), indicating adverse structural remodelling in erectile tissue. In sedentary animals, WBV attenuated several alterations, preserving sperm quality and cavernosal smooth muscle content. However, WBV alone impaired spermatogenesis and increased sperm morphological abnormalities in non\u2010sedentary animals. Serum testosterone levels did not differ significantly. In conclusion, prolonged sedentary behaviour impaired male reproductive indices and induced adverse structural remodelling of penile tissue in male rats. WBV showed context\u2010dependent effects, attenuating alterations under sedentary conditions while showing adverse associations in non\u2010sedentary animals. These findings warrant further translational investigation into the context\u2010dependent effects of WBV on male reproductive and penile tissues.\n                  <\/jats:p>","DOI":"10.1113\/ep094086","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:01:48Z","timestamp":1790949708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Context\u2010dependent effects of whole\u2010body vibration on reproductive function and penile tissue integrity in sedentary male rats"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-8498","authenticated-orcid":false,"given":"Mujdat","family":"Ayva","sequence":"first","affiliation":[{"name":"Department of Urology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-5944","authenticated-orcid":false,"given":"Senay","family":"Akin","sequence":"additional","affiliation":[{"name":"Division of Exercise and Sport Physiology, Faculty of Sport Sciences Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-0988","authenticated-orcid":false,"given":"Irem","family":"Gungor Orhan","sequence":"additional","affiliation":[{"name":"Division of Exercise and Sport Physiology, Faculty of Sport Sciences Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7067-7322","authenticated-orcid":false,"given":"Neslihan","family":"Coskun Akcay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hacettepe University Faculty of Medicine, In\u2010Vitro Fertilization Unit  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-8001","authenticated-orcid":false,"given":"Berkay","family":"Ozerklig","sequence":"additional","affiliation":[{"name":"Division of Exercise and Sport Physiology, Faculty of Sport Sciences Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-0460","authenticated-orcid":false,"given":"Kemal","family":"Kosemehmetoglu","sequence":"additional","affiliation":[{"name":"Department of Pathology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-9954","authenticated-orcid":false,"given":"Mesut","family":"Altan","sequence":"additional","affiliation":[{"name":"Department of Urology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3334-4793","authenticated-orcid":false,"given":"Haydar A.","family":"Demirel","sequence":"additional","affiliation":[{"name":"Center for Sport Sciences Near East University  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3625-9968","authenticated-orcid":false,"given":"Fazil Tuncay","family":"Aki","sequence":"additional","affiliation":[{"name":"Department of Urology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2017.03.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1500174"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002463"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1651"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk7040099"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050067"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-025-04199-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200301000-00002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-00948-5"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"187","article-title":"Whole\u2010body 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