{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:55:17Z","timestamp":1790682917025,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR078903"],"award-info":[{"award-number":["R01 AR078903"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K02 AG081488"],"award-info":[{"award-number":["K02 AG081488"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201020\u201010885"],"award-info":[{"award-number":["W81XWH\u201020\u201010885"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Volumetric muscle loss (VML) is a traumatic skeletal muscle injury characterized by chronic functional impairments in the affected muscle and adjacent uninjured bone. Rehabilitative strategies aimed at restoring limb function following VML, including voluntary running, have shown limited efficacy and in some cases have been detrimental. One potential explanation is disproportional loading of the uninjured contralateral limb during running, but evaluation of unilateral weight\u2010bearing following VML has not been explored. This study was designed to evaluate if the limited response to rehabilitation following VML could be explained by limb loading asymmetry. Twelve\u2010week\u2010old C57Bl\/6J mice (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a024; equal males\/females) were randomized to three groups: Na\u00efve\u2013Run, VML, and VML\u2013Run. Two weeks post\u2010VML, mice in running groups were provided free access to wheels for 6\u00a0weeks. Weight\u2010bearing asymmetry was assessed before injury and biweekly thereafter. Terminally at \u223c20\u00a0weeks of age, in vivo muscle function was evaluated, and muscles and bones were saved for analyses. Prior to injury, no difference in weight\u2010bearing asymmetry was observed across groups. VML\u2010injured mice exhibited similar weight\u2010bearing asymmetries prior to running. Following 6\u00a0weeks of running, VML\u2013Run mice regained weight\u2010bearing symmetry comparable to Na\u00efve\u2013Run. Despite this, remaining muscle function remained persistently impaired following VML injury. Collectively this works suggests that voluntary running promotes favourable weight\u2010bearing adaptations following VML, but does not improve muscle function or the mechanical properties of the adjacent bone.\n                  <\/jats:p>","DOI":"10.1113\/ep094201","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:57:07Z","timestamp":1790679427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Running\u2010based rehabilitation does not improve muscle function after volumetric muscle loss despite improving hindlimb weight\u2010bearing asymmetry in mice"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8258-952X","authenticated-orcid":false,"given":"Angela S.","family":"Bruzina","sequence":"first","affiliation":[{"name":"School of Kinesiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly R.","family":"Weberg","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Willoughby","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7073-8524","authenticated-orcid":false,"given":"Gordon L.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1094-4940","authenticated-orcid":false,"given":"Jarrod A.","family":"Call","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Georgia  Athens Georgia USA"},{"name":"Regenerative Bioscience Center University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-4908","authenticated-orcid":false,"given":"Sarah M.","family":"Greising","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41420-018-0027-8","article-title":"Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury","volume":"4","author":"Aguilar C. A.","year":"2018","journal-title":"Cell Death Discovery"},{"issue":"1","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/2052-1847-6-41","article-title":"Physical rehabilitation improves muscle function following volumetric muscle loss injury","volume":"6","author":"Aurora A.","year":"2014","journal-title":"BioMed Central Sports Science, Medicine & Rehabilitation"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1113\/EP090630","article-title":"Early initiation of electrical stimulation paired with range of motion after a volumetric muscle loss injury does not benefit muscle function","volume":"108","author":"Basten A. M.","year":"2023","journal-title":"Experimental Physiology"},{"issue":"13","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1056\/NEJMc1708134","article-title":"Early versus Delayed Rehabilitation after Acute Muscle Injury","volume":"377","author":"Bayer M. L.","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbr.2018.02.025","article-title":"The structure of arm and hand movements in a spontaneous and food rewarded on\u2010line string\u2010pulling task by the mouse","volume":"345","author":"Blackwell A. A.","year":"2018","journal-title":"Behavioural Brain Research"},{"issue":"3","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/BOT.0000000000000669","article-title":"Lower Extremity Limb Salvage: Lessons Learned From 14 Years at War","volume":"30","author":"Blair J. A.","year":"2016","journal-title":"Journal of Orthopaedic Trauma"},{"issue":"2","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"R243","DOI":"10.1152\/ajpregu.00259.2025","article-title":"Novel assessment of post\u2010prandial metabolism reveals sex\u2010specific metabolic flexibility and lipid remodeling following volumetric muscle loss","volume":"330","author":"Bruzina A. S.","year":"2026","journal-title":"American Journal of Physiology\u2010Regulatory, Integrative and Comparative Physiology"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1186\/s12891-025-09207-5","article-title":"Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice","volume":"26","author":"Bruzina A. S.","year":"2025","journal-title":"BioMed Central Musculoskeletal Disorders"},{"issue":"5","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"R753","DOI":"10.1152\/ajpregu.00187.2025","article-title":"CORP: In vivo muscle strength\u2010perspectives on the design and interpretation of preclinical animal studies","volume":"329","author":"Call J. A.","year":"2025","journal-title":"American Journal of Physiology\u2010Regulatory, Integrative and Comparative Physiology"},{"issue":"7","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"C761","DOI":"10.1152\/ajpcell.00189.2013","article-title":"Autologous minced muscle grafts: A tissue engineering therapy for the volumetric loss of skeletal muscle","volume":"305","author":"Corona B. T.","year":"2013","journal-title":"American Journal of Physiology\u2010Cell Physiology"},{"issue":"11","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1089\/ten.tea.2019.0272","article-title":"Pharmacological mitigation of fibrosis in a porcine model of volumetric muscle loss injury","volume":"26","author":"Corona B. T.","year":"2020","journal-title":"Tissue Engineering Part A"},{"issue":"7","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1682\/JRRD.2014.07.0165","article-title":"Volumetric muscle loss leads to permanent disability following extremity trauma","volume":"52","author":"Corona B. T.","year":"2015","journal-title":"Journal of Rehabilitation Research and Development"},{"issue":"23","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1089\/ten.tea.2022.0113","article-title":"Transcriptomic, Proteomic, and Morphologic Characterization of Healing in Volumetric Muscle Loss","volume":"28","author":"Crum R. J.","year":"2022","journal-title":"Tissue Engineering Part A"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fbioe.2019.00146","article-title":"Analysis and Modeling of Rat Gait Biomechanical Deficits in Response to Volumetric Muscle Loss Injury","volume":"7","author":"Dienes J. A.","year":"2019","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"59","article-title":"The impact of bilateral injuries on the pathophysiology and functional outcomes of volumetric muscle loss","volume":"7","author":"Dolan C. P.","year":"2022","journal-title":"Nature Partner Journal Regenerative Medicine"},{"issue":"1","key":"e_1_2_9_17_1","first-page":"34","article-title":"The effect of mechanical loading upon extracellular matrix bioscaffold\u2010mediated skeletal muscle remodeling","volume":"24","author":"Dziki J. L.","year":"2017","journal-title":"Tissue Engineering Part A"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121818","article-title":"Scalable macroporous hydrogels enhance stem cell treatment of volumetric muscle loss","volume":"290","author":"Eugenis I.","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jor.22730","article-title":"Volumetric muscle loss: Persistent functional deficits beyond frank loss of tissue","volume":"33","author":"Garg K.","year":"2015","journal-title":"Journal of Orthopaedic Research"},{"issue":"17","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.3390\/jcm14176061","article-title":"Rehabilitation Outcomes Following Surgical Management of Lower\u2010Limb Soft Tissue Sarcomas: Insights from Gait Analysis","volume":"14","author":"Germanotta M.","year":"2025","journal-title":"Journal of Clinical Medicine"},{"issue":"6","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1089\/ten.teb.2019.0207","article-title":"Therapeutic approaches for volumetric muscle loss injury: A systematic review and meta\u2010analysis","volume":"25","author":"Greising S. M.","year":"2019","journal-title":"Tissue Engineering Part B: Reviews"},{"issue":"1","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13306-2","article-title":"Unwavering Pathobiology of Volumetric Muscle Loss Injury","volume":"7","author":"Greising S. M.","year":"2017","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12891-018-2095-6","article-title":"Early rehabilitation for volumetric muscle loss injury augments endogenous regenerative aspects of muscle strength and oxidative capacity","volume":"19","author":"Greising S. M.","year":"2018","journal-title":"BioMed Central Musculoskeletal Disorders"},{"issue":"1","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.5435\/00124635-201102001-00007","article-title":"Volumetric muscle loss","volume":"19","author":"Grogan B. F.","year":"2011","journal-title":"Journal of the American Academy of Orthopaedic Surgeons"},{"issue":"20","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1039\/D4BM00616J","article-title":"Age\u2010associated functional healing of musculoskeletal trauma through regenerative engineering and rehabilitation","volume":"12","author":"Habing K. M.","year":"2024","journal-title":"Biomaterials Science"},{"issue":"2","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/03008207.2021.1886285","article-title":"Temporal changes in the muscle extracellular matrix due to volumetric muscle loss injury","volume":"63","author":"Hoffman D. B.","year":"2022","journal-title":"Connective Tissue Research"},{"issue":"3","key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/jor.26023","article-title":"Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of volumetric muscle loss","volume":"43","author":"Hoffman D. B.","year":"2025","journal-title":"Journal of Orthopaedic Research"},{"issue":"1","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/bioengineering9010037","article-title":"Comparative effects of basic fibroblast growth factor delivery or voluntary exercise on muscle regeneration after volumetric muscle loss","volume":"9","author":"Hu C.","year":"2022","journal-title":"Bioengineering"},{"issue":"2","key":"e_1_2_9_29_1","first-page":"122","article-title":"Severe muscle trauma triggers heightened and prolonged local musculoskeletal inflammation and impairs adjacent tibia fracture healing","volume":"16","author":"Hurtgen B. J.","year":"2016","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"issue":"4","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.70246","article-title":"The influence of sex on activity in voluntary wheel running, forced treadmill running, and open field testing in mice","volume":"13","author":"Janowski A. J.","year":"2025","journal-title":"Physiological Reports"},{"issue":"7","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.b.35438","article-title":"Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model","volume":"112","author":"Johnson D.","year":"2024","journal-title":"Journal of Biomedical Materials Research. Part B, Applied Biomaterials"},{"issue":"1","key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1038\/s41467-025-59026-4","article-title":"Acoustofluidic bioassembly induced morphogenesis for therapeutic tissue fabrication","volume":"16","author":"Kang B.","year":"2025","journal-title":"Nature Communications"},{"issue":"4","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/mus.21141","article-title":"Adaptive and nonadaptive responses to voluntary wheel running by mdx mice","volume":"38","author":"Landisch R. M.","year":"2008","journal-title":"Muscle & Nerve"},{"issue":"7","key":"e_1_2_9_34_1","article-title":"Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss","volume":"8","author":"Larouche J. A.","year":"2023","journal-title":"Journal of Clinical Investigation Insight"},{"issue":"9","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jbiomech.2013.10.057","article-title":"Functional analysis of limb recovery following autograft treatment of volumetric muscle loss in the quadriceps femoris","volume":"47","author":"Li M. T.","year":"2014","journal-title":"Journal of Biomechanics"},{"issue":"1","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12951-026-04124-8","article-title":"Ultrasound\u2010activated piezoelectric hydrogel promotes functional muscle repair by orchestrating myogenesis and reinnervation","volume":"24","author":"Lyu Y.","year":"2026","journal-title":"Journal of Nanobiotechnology"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1178213","article-title":"The bioenergetic \u201cCK Clamp\u201d technique detects substrate\u2010specific changes in mitochondrial respiration and membrane potential during early VML injury pathology","volume":"14","author":"McFaline\u2010Figueroa J.","year":"2023","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbaf015","article-title":"Advancing beta\u2010adrenoreceptor agonism for recovery after volumetric muscle loss through regenerative rehabilitation and biomaterial delivery approaches","volume":"12","author":"McFaline\u2010Figueroa J.","year":"2025","journal-title":"Regenerative Biomaterials"},{"issue":"21","key":"e_1_2_9_39_1","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.70612","article-title":"Retrospective transcriptomic analysis indicates temporal dysregulation of mitochondrial genes and metabolic pathways after volumetric muscle loss injury","volume":"13","author":"Miller D. L.","year":"2025","journal-title":"Physiological Reports"},{"issue":"4","key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.3390\/ijms24043564","article-title":"Effects of adjunct antifibrotic treatment within a regenerative rehabilitation paradigm for volumetric muscle loss","volume":"24","author":"Motherwell J. M.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/wound.2024.0109","article-title":"In sequence antifibrotic treatment and rehabilitation after volumetric muscle loss injury","volume":"14","author":"Nicholson P. R.","year":"2025","journal-title":"Adv Wound Care"},{"issue":"8","key":"e_1_2_9_42_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104339","article-title":"Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of Duchenne muscular dystrophy","volume":"9","author":"Novotny S. A.","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nmd.2010.12.002","article-title":"Bone is functionally impaired in dystrophic mice but less so than skeletal muscle","volume":"21","author":"Novotny S. A.","year":"2011","journal-title":"Neuromuscular Disorders"},{"issue":"1","key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1038\/s41467-023-38241-x","article-title":"Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis","volume":"14","author":"Obeidat A. M.","year":"2023","journal-title":"Nature Communications"},{"issue":"1","key":"e_1_2_9_45_1","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15613","article-title":"Bioengineered constructs combined with exercise enhance stem cell\u2010mediated treatment of volumetric muscle loss","volume":"8","author":"Quarta M.","year":"2017","journal-title":"Nature Communications"},{"issue":"1","key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jor.25643","article-title":"Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice","volume":"42","author":"Schifino A. G.","year":"2024","journal-title":"Journal of Orthopaedic Research"},{"issue":"10","key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1113\/EP091284","article-title":"Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury","volume":"108","author":"Schifino A. G.","year":"2023","journal-title":"Experimental Physiology"},{"issue":"5","key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1152\/japplphysiol.00049.2021","article-title":"Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss","volume":"130","author":"Sorensen J. R.","year":"2021","journal-title":"Journal of Applied Physiology"},{"issue":"1","key":"e_1_2_9_49_1","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1038\/s41598-019-40606-6","article-title":"PGC\u20101\u03b1 overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury","volume":"9","author":"Southern W. M.","year":"2019","journal-title":"Scientific Reports"},{"issue":"5","key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1152\/jappl.1996.80.5.1660","article-title":"Estradiol effect on anterior crural muscles\u2010tibial bone relationship and susceptibility to injury","volume":"80","author":"Warren G. L.","year":"1996","journal-title":"Journal of Applied Physiology"},{"issue":"5","key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"R2015","DOI":"10.1152\/ajpregu.00569.2007","article-title":"Voluntary run training but not estradiol deficiency alters the tibial bone\u2010soleus muscle functional relationship in mice","volume":"293","author":"Warren G. L.","year":"2007","journal-title":"American Journal of Physiology\u2010Regulatory, Integrative and Comparative Physiology"},{"issue":"2","key":"e_1_2_9_52_1","first-page":"152","article-title":"Moderate tibia axial loading promotes discordant response of bone composition parameters and mechanical properties in a hindlimb unloading rat model","volume":"18","author":"Yang P. F.","year":"2018","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"issue":"12","key":"e_1_2_9_53_1","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1002\/jor.25591","article-title":"Electrically stimulated eccentric contraction training enhances muscle mass, function, and size following volumetric muscle loss","volume":"41","author":"Ziemkiewicz N.","year":"2023","journal-title":"Journal of Orthopaedic Research"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP094201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP094201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP094201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:57:15Z","timestamp":1790679435000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP094201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":52,"alternative-id":["10.1113\/EP094201"],"URL":"https:\/\/doi.org\/10.1113\/ep094201","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"EP094201"}}