{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:48:31Z","timestamp":1761806911971},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,5,5]],"date-time":"2004-05-05T00:00:00Z","timestamp":1083715200000},"content-version":"vor","delay-in-days":1100,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>The aim of this study was to investigate the role of the parasympathetic (cholinergic and peptidergic) nervous system in the regulation of exocrine pancreas function in piglets during their early postnatal development. The cholinergic and peptidergic regulatory pathways of exocrine pancreatic function were tested by the specific muscarinic receptor blocker 4\u2010diphenylacetoxy\u2010<jats:italic>N<\/jats:italic>\u2010methylpiperidine\u2010methiodide (4\u2010DAMP) and bombesin, respectively. At the age of 2 weeks, piglets were surgically fitted with a chronic pancreatic duct catheter, a duodenal re\u2010entrant cannula and a jugular vein catheter. The experiments comprised a pre\u2010weaning period, and a post\u2010weaning period that commenced at the beginning of the 5th week of age. Intravenous infusion of 4\u2010DAMP (100 pmol kg<jats:sup>\u22121<\/jats:sup> h<jats:sup>\u22121<\/jats:sup>) reduced the outflow of pancreatic juice, the output of total protein and the activity of trypsin, chymotrypsin, carboxyl ester hydrolase and amylase during preprandial and postprandial pancreatic secretion, in both the pre\u2010 and post\u2010weaning periods. However, the inhibitory effect of 4\u2010DAMP during postprandial secretion was significantly greater (<jats:italic>P<\/jats:italic> &lt; 0.05) in suckling piglets. The infusion of bombesin (10, 100 and 1000 pmol kg<jats:sup>\u22121<\/jats:sup> h<jats:sup>\u22121<\/jats:sup>) stimulated exocrine pancreatic secretion in a dose\u2010dependent manner during both the pre\u2010 and post\u2010weaning periods. However, the stimulatory effect of 1000 pmol kg<jats:sup>\u22121<\/jats:sup> h<jats:sup>\u22121<\/jats:sup> bombesin on total protein output and the activities of trypsin, chymotrypsin and amylase were significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.05) in suckling piglets. In summary, our study showed that cholinergic and peptidergic mechanisms are involved in the regulation of exocrine pancreas function in piglets in both the pre\u2010 and post\u2010weaning stages. 4\u2010DAMP had a greater inhibitory effect on exocrine pancreatic secretion in piglets during the pre\u2010weaning period. Thus, these observations suggest that the parasympathetic nervous system plays a dominant role in the functioning of the exocrine pancreas at this time. The action of bombesin suggests that it is a potent secretagogue for the exocrine pancreas in pigs during their postnatal development.<\/jats:p>","DOI":"10.1113\/eph8602151","type":"journal-article","created":{"date-parts":[[2003,2,11]],"date-time":"2003-02-11T16:34:49Z","timestamp":1044981289000},"page":"399-409","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Cholinergic and Peptidergic Pathways in the Regulation of Pancreatic Exocrine Function During Postnatal Development in Pigs"],"prefix":"10.1113","volume":"86","author":[{"given":"V.","family":"Lesniewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gregard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Westr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Hedemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. N.","family":"L\u00e6rke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kruszewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. G.","family":"Pierzynowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,5]]},"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Feph8602151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Feph8602151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/eph8602151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:25:38Z","timestamp":1700418338000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/eph8602151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1113\/eph8602151"],"URL":"https:\/\/doi.org\/10.1113\/eph8602151","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}