{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:39:33Z","timestamp":1791301173848,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T00:00:00Z","timestamp":1083628800000},"content-version":"vor","delay-in-days":854,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>Experiments were carried out to determine if endogenous pyrogen\u2010induced fever impairs protective responses of newborn rats to hypoxia. Twenty\u2010seven 5\u2010 to 6\u2010day\u2010old conscious rat pups received a subcutaneous injection of 0.20 \u03bcg of recombinant rat interleukin\u20101\u03b2 (rrIL\u20101\u03b2) per kilogram of body weight to induce fever, or an equal volume of vehicle. They were then either exposed to a single period of hypoxia produced by breathing an anoxic gas mixture (97% N<jats:sub>2<\/jats:sub>\u20103% CO<jats:sub>2<\/jats:sub>) and their time to last gasp was determined, or they were exposed repeatedly to hypoxia and their ability to autoresuscitate from primary apnoea was determined. Core temperature increased significantly following administration of rrIL\u20101\u03b2 but did not change following administration of vehicle (i.e. vehicle, 0.0 \u00b1 0.1 \u00b0C; rrIL\u20101\u03b2, 0.7 \u00b1 0.3 \u00b0C; P &lt; 0.001) before exposure to hypoxia. IL\u20101\u03b2\u2010induced fever did not alter the time to last gasp when the pups were exposed to a single period of hypoxia or the number of successful autoresuscitations upon repeated exposure to hypoxia. Thus, our data do not support the hypothesis that endogenous pyrogen\u2010induced fever impairs the protective responses in newborns that may prevent death during hypoxia as may occur during single or repeated episodes of prolonged sleep apnoea.<\/jats:p>","DOI":"10.1113\/eph8702271","type":"journal-article","created":{"date-parts":[[2003,2,11]],"date-time":"2003-02-11T16:35:21Z","timestamp":1044981321000},"page":"17-24","source":"Crossref","is-referenced-by-count":8,"title":["Interleukin\u20101\u03b2\u2010Induced Fever Does not Alter the Ability of 5\u2010 to 6\u2010Day\u2010Old Rat Pups to Autoresuscitate from Hypoxia\u2010Induced Apnoea"],"prefix":"10.1113","volume":"87","author":[{"given":"James E.","family":"Fewell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa H.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,4]]},"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Feph8702271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Feph8702271","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/eph8702271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:05:03Z","timestamp":1700251503000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/eph8702271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1113\/eph8702271"],"URL":"https:\/\/doi.org\/10.1113\/eph8702271","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}