{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:36:29Z","timestamp":1699490189451},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1980,10,10]],"date-time":"1980-10-10T00:00:00Z","timestamp":339984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Physiol"],"published-print":{"date-parts":[[1980,10,10]]},"abstract":"<jats:p>Contractures can be evoked from frog atrial trabeculae by raising extracellular pH in Na\u2010free fluid after the spontaneous relaxation of the teision evoked by removineg extracellular Na. These alkalinity contractures are unffected by local anaesthetics but are absent following a brief perfusion with Ca\u2010free fluid containing EGTA. The application of ammonium chloride produces similar\u2010contractures which are unaffected by perfusion with Ca\u2010free fluid but are partially inhibited by local analesthetics. Perfusioni by solution containing a high Pco<jats:sub>2<\/jats:sub> fails to induce contractures.<\/jats:p><jats:p>The relationship between [Na]<jats:sub>o<\/jats:sub> and tension is altered by changing extracellur pH: acidic fluids below pH 6\u00b70 reduce tension and alkaline fluids increase tenision over the whole range. NH<jats:sub>4<\/jats:sub>Cl has the same effect as alkalinc fluids while CO<jats:sub>2<\/jats:sub>\u2010conitaining flid has no effect. These results can be interpreted if the effects of variation of extracelluar pH. on Na\u2010withdrawa; contractures, are mediated by changes in intracellular pH which in turn affect the Ca\u2010sensitivity of the contractile proteins.<\/jats:p>","DOI":"10.1113\/expphysiol.1980.sp002522","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T18:06:18Z","timestamp":1418753178000},"page":"349-366","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of pH on the Sodium\u2010Withdrawal Contractures Evoked from Frog Atrial Trabeculae"],"prefix":"10.1113","volume":"65","author":[{"given":"R. A.","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1980,10,10]]},"container-title":["Quarterly Journal of Experimental Physiology and Cognate Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.1980.sp002522","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.1980.sp002522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:39:53Z","timestamp":1699450793000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.1980.sp002522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,10,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,10,10]]}},"alternative-id":["10.1113\/expphysiol.1980.sp002522"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.1980.sp002522","archive":["Portico"],"relation":{},"ISSN":["0033-5541"],"issn-type":[{"value":"0033-5541","type":"print"}],"subject":[],"published":{"date-parts":[[1980,10,10]]}}}