{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:15:39Z","timestamp":1773962139299,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1983,1,22]],"date-time":"1983-01-22T00:00:00Z","timestamp":412041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Physiol"],"published-print":{"date-parts":[[1983,1,22]]},"abstract":"<jats:p>Rat respiratory muscles underwent considerable changes in histochemical fibre type profile in response to hypo\u2010 and hyperthyroidism. Hypothyroidism increased the proportion of type 1 slow oxidative fibres in diaphragm and to a lesser extent in intercostal muscles. Hyperthyroidism resulted in a decreased proportion of type 1 fibres in both diaphragm and intercostals. These changes were broadly comparable to those reported previously in rat limb muscles. In normal rat respiratory muscles, the type 1 fibres were characterized by very high levels of \u03b2\u2010hydroxybutyrate dehydrogenase which was thought to contribute to the fatigue\u2010resistance of these muscles. The type 2B fast glycolytic fibres, and to a lesser extent type 2A fast oxidative fibres, contained high levels of mitochondrial \u03b1\u2010glycerophosphate dehydrogenase, an enzyme known to be specifically affected in dysthyroid states. The implications of the observed changes in fibre type profile with respect to the oxidative metabolism of rat respiratory muscles are discussed.<\/jats:p>","DOI":"10.1113\/expphysiol.1983.sp002689","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T17:14:20Z","timestamp":1418750060000},"page":"1-13","source":"Crossref","is-referenced-by-count":24,"title":["CHANGES IN HISTOCHEMICAL PROFILE OF RAT RESPIRATORY MUSCLES IN HYPO\u2010AND HYPERTHYROIDISM"],"prefix":"10.1113","volume":"68","author":[{"given":"M. A.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Olmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. L.","family":"Mastaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,1,22]]},"container-title":["Quarterly Journal of Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.1983.sp002689","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.1983.sp002689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:08:28Z","timestamp":1697749708000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.1983.sp002689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1,22]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1,22]]}},"alternative-id":["10.1113\/expphysiol.1983.sp002689"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.1983.sp002689","archive":["Portico"],"relation":{},"ISSN":["0144-8757"],"issn-type":[{"value":"0144-8757","type":"print"}],"subject":[],"published":{"date-parts":[[1983,1,22]]}}}