{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:19:18Z","timestamp":1770509958517,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1989,11,12]],"date-time":"1989-11-12T00:00:00Z","timestamp":626832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Physiol"],"published-print":{"date-parts":[[1989,11,12]]},"abstract":"<jats:p>Biochemical parameters of Ca homeostasis in fetal and maternal plasma and placental transfer of Ca, P<jats:sub>i<\/jats:sub> and vitamin D metabolites were measured during pregnancy and at parturition. Control pigs and pigs with inherited pseudo\u2010vitamin D\u2010deficiency rickets, type I (PVDR), which are devoid of renal calcitriol production, were used. Although sows with PVDR normally require treatment with massive doses of vitamin D at intervals of 4 weeks to stabilize Ca and P<jats:sub>i<\/jats:sub> concentrations in plasma, these plasma parameters tended to normalize during the first 3 months of pregnancy when the vitamin D treatment was discontinued about 4 weeks before conception. In homozygote sows plasma calcitriol concentrations remained unphysio\u2010logically low and the 25OHD<jats:sub>3<\/jats:sub> concentrations increased steadily during pregnancy reaching higher levels than those found in control sows. Despite hypocalcaemia and hypophosphataemia of the homozygote sows at term, fetal Ca and P<jats:sub>i<\/jats:sub> concentrations were normal. This demonstrated a higher feto\u2010maternal concentration gradient in PVDR pigs than in control pigs. It is concluded that maintenance of Ca and P<jats:sub>i<\/jats:sub> homeostasis of the feto\u2010maternal system, including active transplacental transport in pigs, is at least partly independant from calcitriol.<\/jats:p>","DOI":"10.1113\/expphysiol.1989.sp003358","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T15:28:43Z","timestamp":1418743723000},"page":"875-881","source":"Crossref","is-referenced-by-count":25,"title":["ROLE OF 1,25\u2010(OH)<sub>2<\/sub>D<sub>3<\/sub> DURING PREGNANCY; STUDIES WITH PIGS SUFFERING FROM PSEUDO\u2010 VITAMIN D\u2010DEFICIENCY RICKETS, TYPE I"],"prefix":"10.1113","volume":"74","author":[{"given":"Ute","family":"Lachenmaier\u2010Currle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Breves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Harmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,11,12]]},"container-title":["Quarterly Journal of Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.1989.sp003358","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.1989.sp003358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T05:44:43Z","timestamp":1697953483000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.1989.sp003358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,11,12]]}},"alternative-id":["10.1113\/expphysiol.1989.sp003358"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.1989.sp003358","archive":["Portico"],"relation":{},"ISSN":["0144-8757"],"issn-type":[{"value":"0144-8757","type":"print"}],"subject":[],"published":{"date-parts":[[1989,11,12]]}}}