{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:32:43Z","timestamp":1751376763998},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1989,11,12]],"date-time":"1989-11-12T00:00:00Z","timestamp":626832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Physiol"],"published-print":{"date-parts":[[1989,11,12]]},"abstract":"<jats:p>The transport of K<jats:sup>+<\/jats:sup> (using <jats:sup>86<\/jats:sup>Rb as tracer) by lactating rat mammary tissue slices has been studied in order to seek evidence for Na<jats:sup>+<\/jats:sup>\u2010K<jats:sup>+<\/jats:sup>\u2010Cl<jats:sup>\u2212<\/jats:sup> co\u2010transport. Potassium transport was inhibited by furosemide; the locus of inhibition was at a site other than the Na<jats:sup>+<\/jats:sup>:K<jats:sup>+<\/jats:sup> pump. Replacing medium Cl<jats:sup>\u2212<\/jats:sup> with NO<jats:sub>3<\/jats:sub> reduced the bidirectional movement of K<jats:sup>+<\/jats:sup>; moreover, furosemide was without effect in a Cl<jats:sup>\u2212<\/jats:sup>\u2010free medium. Sodium replacement by <jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010glucamine acted to reduce the loop diuretic\u2010sensitive component of K<jats:sup>+<\/jats:sup> uptake whilst concomitantly increasing K<jats:sup>+<\/jats:sup> influx via an ouabain\u2010and furosemide\u2010resistant pathway. Potassium efflux was found to be transiently stimulated by Na<jats:sup>+<\/jats:sup> ions; this was attenuated by furosemide. Potassium egress was markedly increased via a furosemide\u2010insensitive pathway when salicylate was used to replace Cl<jats:sup>\u2212<\/jats:sup>. The results are consistent with furosemide\u2010sensitive Na<jats:sup>+<\/jats:sup>\u2010K<jats:sup>+<\/jats:sup>\u2010Cl<jats:sup>\u2212<\/jats:sup>co\u2010transport.<\/jats:p>","DOI":"10.1113\/expphysiol.1989.sp003363","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T15:28:43Z","timestamp":1418743723000},"page":"927-938","source":"Crossref","is-referenced-by-count":24,"title":["EVIDENCE FOR FUROSEMID E\u2010SENSITIVE Na<sup>+<\/sup>\u2010K<sup>+<\/sup>\u2010Cl<sup>#x2212;<\/sup> CO\u2010TRANSPORT IN LACTATING RAT MAMMARY TISSUE"],"prefix":"10.1113","volume":"74","author":[{"given":"D. B.","family":"Shennan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,11,12]]},"container-title":["Quarterly Journal of Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.1989.sp003363","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.1989.sp003363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T05:44:27Z","timestamp":1697953467000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.1989.sp003363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,11,12]]}},"alternative-id":["10.1113\/expphysiol.1989.sp003363"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.1989.sp003363","archive":["Portico"],"relation":{},"ISSN":["0144-8757"],"issn-type":[{"value":"0144-8757","type":"print"}],"subject":[],"published":{"date-parts":[[1989,11,12]]}}}