{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:00:47Z","timestamp":1773658847946,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>Oxytocin\u2010induced contractions of isolated strips of oestradiol\u2010treated rat myometrium were found to be affected by exposure to the diuretic frusemide. At a concentration of 20 microM. frusemide transiently increased the force of contraction over a period of approximately 10 min. After this time there was a progressive fall in contractile force. At a higher concentration of 200 microM, only the progressive fall in force was seen until contractions were completely abolished. Frusemide has been reported to increase the activity of cAMP\u2010phosphodiesterase in tissue extracts from oestradiol\u2010treated rat myometrium. Therefore, the changes in contraction due to exposure to frusemide may be a reflection of the changes in intracellular cAMP resulting from a stimulation of cAMP\u2010phosphodiesterase activity. In support of this idea, addition of dibutyryl cAMP was found to partially restore contractions after frusemide treatment. These data suggest that frusemide may be a useful tool in the manipulation of tissue cAMP levels in order to determine the different roles of cAMP in the oestradiol\u2010treated rat myometrium.<\/jats:p>","DOI":"10.1113\/expphysiol.1994.sp003798","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T13:16:02Z","timestamp":1418735762000},"page":"661-667","source":"Crossref","is-referenced-by-count":9,"title":["The effect of frusemide on oxytocin\u2010induced contractions of the rat myometrium"],"prefix":"10.1113","volume":"79","author":[{"given":"MG","family":"Mozhayeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YaYu","family":"Bagrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IB","family":"Ostretsova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JI","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,9]]},"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.1994.sp003798","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.1994.sp003798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T16:38:52Z","timestamp":1698165532000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.1994.sp003798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1113\/expphysiol.1994.sp003798"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.1994.sp003798","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}