{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:06:11Z","timestamp":1767852371629,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>Electrogenic chloride and bicarbonate secretion by cultured rat epididymal epithelia was studied using the short\u2010circuit current (ISC) technique. When incubated in normal solution, 8\u2010(4\u2010chlorophenylthio)\u2010adenosine 3',5'\u2010cyclic monophosphate (cpt\u2010cAMP) caused a rise in the ISC, which was attributable to Cl\u2010 and HCO3\u2010 secretion. Cl\u2010 secretion was found to contribute to the initial transient phase, whereas HCO3\u2010 secretion contributed to the sustained phase of the response. HCO3\u2010 secretion involves a basolaterally placed Na(+)\u2010H+ exchanger and apical anion channel, most probably the cystic fibrosis transmembrane conductance regulator (CFTR). There is also evidence that an apical electrogenic Na(+)\u2010HCO3\u2010 cotransporter is involved in HCO3\u2010 exit. CFTR accounted for 70% of HCO3\u2010 secretion, while the Na(+)\u2010HCO3\u2010 cotransporter accounted for 30%. The possibility that the cotransporter may serve as an alternative pathway for HCO3\u2010 secretion in cystic fibrosis is discussed.<\/jats:p>","DOI":"10.1113\/expphysiol.1996.sp003954","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T12:25:28Z","timestamp":1418732728000},"page":"515-524","source":"Crossref","is-referenced-by-count":28,"title":["Evidence for independent Cl\u2010 and HCO3\u2010 secretion and involvement of an apical Na(+)\u2010HCO3\u2010 cotransporter in cultured rat epididymal epithelia"],"prefix":"10.1113","volume":"81","author":[{"given":"HC","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WH","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WO","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PY","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,5]]},"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.1996.sp003954","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.1996.sp003954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T06:48:11Z","timestamp":1698389291000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.1996.sp003954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["10.1113\/expphysiol.1996.sp003954"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.1996.sp003954","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}