{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T05:38:56Z","timestamp":1734500336639,"version":"3.30.2"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T00:00:00Z","timestamp":1092873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p><jats:bold>Hypokalaemia increases the risk for life\u2010threatening arrhythmias; however, data about interaction with thyroid status are lacking. The aim of this study was to investigate vulnerability of<jats:sc>l<\/jats:sc>\u2010thyroxine (T<jats:sub>4<\/jats:sub>)\u2010treated adult and old rats to low K<jats:sup>+<\/jats:sup>\u2010induced ventricular fibrillation (VF) as well as the ability of the heart to recover sinus rhythm. The experiments were performed on isolated heart preparations using the heart of 4\u2010 and 20\u2010month\u2010old female Wistar rats without and with feeding with T<jats:sub>4<\/jats:sub>50 \u03bcg (100 g day)<jats:sup>\u22121<\/jats:sup>over a period of 2 weeks. Perfusion of the isolated heart with oxygenated Krebs\u2013Henseleit solution at constant pressure was followed by perfusion with K<jats:sup>+<\/jats:sup>\u2010deficient solution until occurrence of VF (&lt; 10 min). After 2 min of sustained VF, the heart was perfused with normal solution for 10 min, during which sinus rhythm was restored. ECG, left ventricular pressure (LVP) and coronary flow were continuously monitored. The results showed that compared with untreated rats, the onset of low K<jats:sup>+<\/jats:sup>\u2010induced ventricular premature beats was delayed and their number was significantly decreased in both T<jats:sub>4<\/jats:sub>\u2010treated groups. Nevertheless, VF occurred earlier in T<jats:sub>4<\/jats:sub>\u2010treated than in non\u2010treated adult rats (6.78 \u00b1 0.28<jats:italic>vs.<\/jats:italic>9.59 \u00b1 0.55 min,<jats:italic>P<\/jats:italic>&lt; 0.05), whereas the difference was not significant in aged animals. Furthermore, sinus rhythm appeared earlier in old T<jats:sub>4<\/jats:sub>\u2010treated rats compared with non\u2010treated rats (7.18 \u00b1 0.57<jats:italic>vs.<\/jats:italic>8.94 \u00b1 0.64 min,<jats:italic>P<\/jats:italic>&lt; 0.05), whereas in adult hearts it set in at practically the same time regardless of treatment. In conclusion, our results indicate that administration of a pharmacological dose of T<jats:sub>4<\/jats:sub>can increase the risk of low K<jats:sup>+<\/jats:sup>\u2010induced VF in adult but not in old animals; in the latter it even facilitated restoration of sinus rhythm. Moreover, enhanced mechanical function was observed in both adult and old T<jats:sub>4<\/jats:sub>\u2010treated hearts.<\/jats:bold><\/jats:p>","DOI":"10.1113\/expphysiol.2004.027607","type":"journal-article","created":{"date-parts":[[2004,7,16]],"date-time":"2004-07-16T00:16:00Z","timestamp":1089936960000},"page":"629-636","source":"Crossref","is-referenced-by-count":4,"title":["L\u2010thyroxine increases susceptibility of adult rats to low K<sup>+<\/sup>\u2010induced ventricular fibrillation, and sinus rhythm restoration in old rats"],"prefix":"10.1113","volume":"89","author":[{"given":"Narcis","family":"Tribulova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Knezl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Okruhlicova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Drimal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalma","family":"Lamosova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Slezak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Styk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(18)30292-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584774"},{"key":"e_1_2_5_4_1","first-page":"4701","article-title":"Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle\u2010aged patients","volume":"85","author":"Biondi B","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760143872"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb27466.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760143818"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.1.H264"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.6.2672"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01295.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.5.703"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(05)80288-2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2.11.1877"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960230605"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90336-0"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(94)50055-X"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760143917"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.2.332"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.44.101"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-12-1014"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.27.365"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-510150-9.50008-0"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.4.988"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760143863"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.33549\/physiolres.930013","article-title":"Dispersion of cell\u2010to\u2010cell uncoupling precedes low K+\u2010induced ventricular fibrillation","volume":"50","author":"Tribulova N","year":"2001","journal-title":"Physiol Res"},{"key":"e_1_2_5_26_1","first-page":"369","article-title":"Factors involved in the susceptibility of spontaneously hypertensive rats to low K+\u2010induced arrhythmias","volume":"22","author":"Tribulova N","year":"2003","journal-title":"Gen Physiol Biophys"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702336"},{"key":"e_1_2_5_28_1","first-page":"377","volume-title":"Cardiac Remodeling and Failure","author":"Tribulova N","year":"2002"},{"key":"e_1_2_5_29_1","article-title":"Enhanced connexin 43 and alfa sarcomeric actin expression in cultured heart myocytes exposed to triiodo\u20101\u2010thyronine","volume":"35","author":"Tribulova N","year":"2004","journal-title":"Histochem J"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19940150"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1097"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2004.027607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2004.027607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.2004.027607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T22:14:51Z","timestamp":1734473691000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.2004.027607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,19]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1113\/expphysiol.2004.027607"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2004.027607","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"type":"print","value":"0958-0670"},{"type":"electronic","value":"1469-445X"}],"subject":[],"published":{"date-parts":[[2004,8,19]]}}}