{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:14:14Z","timestamp":1771672454804,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T00:00:00Z","timestamp":1103587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>The present study was designed to analyse the effects of aerobic exercise on the metabolic effects of alloxan. Male Wistar newborn rats (2 days old) received alloxan (200 mg (kg body weight)<jats:sup>\u22121<\/jats:sup>) intraperitoneally (A rats). Vehicle\u2010injected rats were used as controls (C rats). At 28 days old, some of the A rats were subjected to swimming for 1 h day<jats:sup>\u22121<\/jats:sup>, 5 day week<jats:sup>\u22121<\/jats:sup> (AT rats). At 28, 60 and 90 days old the animals were subjected to glucose (GTTo) and insulin (ITTsc) tolerance tests. All the animals were then killed by decapitation for blood and tissue evaluations. On the 60th day, there was a reduction in blood glucose level during the GTTo (mmol l<jats:sup>\u22121<\/jats:sup> (90 min)<jats:sup>\u22121<\/jats:sup>) in the AT rats (7640.7 \u00b1 694.0) with respect to C (7057.5 \u00b1 776.9) and A (8555.6 \u00b1 1096.7) rats. However on the 90th day, AT rats showed higher glucose levels (8004.6 \u00b1 267.9) when compared to the other groups (C, 7305.5 \u00b1 871.2; A, 7088.8 \u00b1 536.9). The serum free fatty acid (FFA) concentration (\u03bcEq l<jats:sup>\u22121<\/jats:sup>) was higher in the alloxan\u2010treated animals (A, 231.1 \u00b1 58.5; AT, 169.8 \u00b1 20.1) than in controls (C, 101.4 \u00b1 22.4). In conclusion, although the high blood glucose level is transitory in the A animals, some blood and tissue alterations remain and can be harmful to the maintenance of homeostasis. Physical exercise counteracted only partially these alterations. Furthermore, training worsened glucose tolerance at the 90th day, suggesting that exercise intensity should be adjusted to the diabetic condition.<\/jats:bold><\/jats:p>","DOI":"10.1113\/expphysiol.2004.028241","type":"journal-article","created":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T00:12:56Z","timestamp":1096935176000},"page":"79-86","source":"Crossref","is-referenced-by-count":11,"title":["The role of exercise on long\u2010term effects of alloxan administered in neonatal rats"],"prefix":"10.1113","volume":"90","author":[{"given":"Camila Aparecida Machado","family":"De Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliete","family":"Luciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alice Rostom","family":"De 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