{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:26:37Z","timestamp":1697088397511},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,7,13]],"date-time":"2005-07-13T00:00:00Z","timestamp":1121212800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p><jats:bold>The effect of sodium nitroprusside (SNP) on carbachol (CCh)\u2010evoked inward cationic current (<jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub>) oscillations in guinea\u2010pig ileal longitudinal myocytes was investigated using the whole\u2010cell patch\u2010clamp technique and permeabilized longitudinal muscle strips. SNP (10 \u03bc<jats:sc>m<\/jats:sc>) completely inhibited <jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub> oscillations evoked by 1 \u03bc<jats:sc>m<\/jats:sc> CCh. 1H\u2010(1,2,4) Oxadiazole [4,3\u2010a] quinoxaline\u20101\u2010one (ODQ; 1 \u03bc<jats:sc>m<\/jats:sc>) almost completely prevented the inhibitory effect of SNP on <jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub> oscillations. 8\u2010Bromo\u2010guanosine 3\u2032,5\u2032\u2010cyclic monophosphate (8\u2010Br\u2010cGMP; 30 \u03bc<jats:sc>m<\/jats:sc>) in the pipette solution completely abolished <jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub> oscillations. However, a pipette solution containing Rp\u20108\u2010Br\u2010cGMP (30 \u03bc<jats:sc>m<\/jats:sc>) almost completely abolished the inhibitory effect of SNP on <jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub> oscillations. When the intracellular calcium concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>) was held at a resting level using BAPTA (10 m<jats:sc>m<\/jats:sc>) and Ca<jats:sup>2+<\/jats:sup> (4.6 \u03bc<jats:sc>m<\/jats:sc>) in the pipette solution, CCh (1 \u03bc<jats:sc>m<\/jats:sc>) evoked only the sustained component of <jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub> without any oscillations and SNP did not affect the current. A high concentration of inositol 1,4,5\u2010trisphosphate (IP<jats:sub>3<\/jats:sub>; 30 \u03bc<jats:sc>m<\/jats:sc>) in the patch pipette solutions significantly reduced the inhibitory effect of SNP (10 \u03bc<jats:sc>m<\/jats:sc>) on <jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub> oscillations. SNP significantly inhibited the Ca<jats:sup>2+<\/jats:sup> release evoked by either CCh or IP<jats:sub>3<\/jats:sub> but not by caffeine in permeabilized preparations of longitudinal muscle strips. These results suggest that the inhibitory effects of SNP on <jats:italic>I<\/jats:italic><jats:sub>cat<\/jats:sub> oscillations are mediated, in part, by functional modulation of the IP<jats:sub>3<\/jats:sub> receptor, and not by the inhibition of cationic channels themselves or by muscarinic receptors in the plasma membrane. This inhibition seems to be mediated by an increased cGMP concentration in a protein kinase G\u2010dependent manner.<\/jats:bold><\/jats:p>","DOI":"10.1113\/expphysiol.2004.029611","type":"journal-article","created":{"date-parts":[[2005,4,16]],"date-time":"2005-04-16T00:13:10Z","timestamp":1113610390000},"page":"577-586","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of carbachol\u2010evoked oscillatory currents by the NO donor sodium nitroprusside in guinea\u2010pig ileal 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