{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:06:33Z","timestamp":1791029193581,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,7,13]],"date-time":"2005-07-13T00:00:00Z","timestamp":1121212800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p><jats:bold>Non\u2010steroidal anti\u2010inflammatory drugs are frequently prescribed after skeletal muscle injury. It is not known whether this type of medication can interfere with muscle repair, although inflammatory response is thought to play an important role in this process. <jats:italic>Tibialis anterior<\/jats:italic> muscles of mice were injured by myotoxic agent (snake venom) or crushed. Then, animals were treated daily for 10\u201314 days with different types of non\u2010steroidal anti\u2010inflammatory and antioxidant drugs. The long\u2010term repair was studied 10\u201342 days after injury by analysing the recovery of <jats:italic>in situ<\/jats:italic> muscle force production, size of regenerating muscle cells and expression of myosin heavy chain. Our results show that diclofenac, diferuloylmethane (curcumin), dimethylthiourea or pyrrolidine dithiocarbamate treatment did not significantly affect muscle recovery after myotoxic injury (<jats:italic>P<\/jats:italic> &gt; 0.05). Similarly, diferuloylmethane, dimethyl sulphoxide or indomethacin administration did not markedly change muscle repair after crush injury. However, we noted that high doses (&gt; 2 mg kg<jats:sup>\u22121<\/jats:sup>) of diferuloylmethane or indomethacin increased lethality and reduced muscle repair after crush injury. In conclusion, non\u2010steroidal anti\u2010inflammatory and antioxidant drugs did not exhibit long\u2010term detrimental effects on muscle recovery after injury, except at lethal doses.<\/jats:bold><\/jats:p>","DOI":"10.1113\/expphysiol.2005.029835","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T04:44:21Z","timestamp":1109133861000},"page":"487-495","source":"Crossref","is-referenced-by-count":37,"title":["Effect of anti\u2010inflammatory and antioxidant drugs on the long\u2010term repair of severely injured mouse skeletal 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