{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:54:06Z","timestamp":1790988846280,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,14]],"date-time":"2005-09-14T00:00:00Z","timestamp":1126656000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p><jats:bold>Obesity in humans causes hypertension, myocardial hypertrophy and coronary atherosclerosis, and increased cardiovascular morbidity and mortality that is thought to be related to sympathetic overactivity. Leptin is an adipocyte\u2010derived hormone that acts in the hypothalamus to regulate appetite, energy expenditure and sympathetic nervous system outflow. One of the major mechanisms leading to the development of obesity\u2010induced hypertension appears to be leptin\u2010mediated sympatho\u2010activation. Leptin adversely shifts the renal pressure\u2013natriuresis curve, leading to relative sodium retention. Although obesity is generally associated with resistance to the anorexic and weight\u2010reducing actions of leptin, our work has shown preservation of its sympatho\u2010excitatory and pressor actions. This selective leptin resistance of obesity, coupled with hyperleptinaemia, may play a critical role in the cardiovascular complications of obesity. Increased information about leptin and its mechanisms of actions should help the development of safe and effective pharmacological treatments of obesity and obesity\u2010related hypertension.<\/jats:bold><\/jats:p>","DOI":"10.1113\/expphysiol.2005.031237","type":"journal-article","created":{"date-parts":[[2005,8,17]],"date-time":"2005-08-17T02:29:07Z","timestamp":1124245747000},"page":"683-688","source":"Crossref","is-referenced-by-count":89,"title":["Role of leptin in obesity\u2010related hypertension"],"prefix":"10.1113","volume":"90","author":[{"given":"William 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