{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:00:54Z","timestamp":1773079254556,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T00:00:00Z","timestamp":1135036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Interdigestive intestinal motility, and especially phase III of the migrating myoelectric\/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal microflora can themselves affect the characteristics of the myoelectric activity of the gut during the interdigestive state. Given that the composition of the intestinal microflora can be altered by dietary manipulations, we investigated the effect of supplementation of the diet with synbiotics on intestinal microflora structure and the duodenojejunal myoelectric activity in the rat. To reduce animal distress caused by restraint and handling, which can itself affect GI motility, we applied radiotelemetry for duodenojejunal EMG recordings in conscious, freely moving rats. Thirty 16\u2010month\u2010old Spraque\u2013Dawley rats were used. The diet for 15 rats (E group) was supplemented with chicory inulin, <jats:italic>Lactobacillus rhamnosus<\/jats:italic> and <jats:italic>Bifidobacterium lactis<\/jats:italic>. The remaining 15 rats were fed control diet without supplements (C group). Three rats from each group were implanted with three bipolar electrodes positioned at 2, 14 and 28 cm distal to the pylorus. After recovery, two 6 h recordings of duodenojejunal EMG were carried out on each operated rat. Subsequently, group C rats received feed supplements and group E rats received only control diet for 1 week, and an additional two 6 h recordings were carried out on each of these rats. Non\u2010operated C and E rats were killed and samples of GI tract were collected for microbiological analyses. Supplementation of the diet with the pro\u2010 and prebiotics mixture increased the number of bifidobacteria, whereas it decreased the number of enterobacteria in jejunum, ileum, caecum and colon. In both caecum and colon, the dietary supplementation increased the number of total anaerobes and lactobacilli. Treatment with synbiotics increased occurrence of phase III of the MMC at all three levels of the small intestine. The propagation velocity of phase III in the whole recording segment was also increased from 3.7 \u00b1 0.2 to 4.4 \u00b1 0.2 cm min<jats:sup>\u22121<\/jats:sup> by dietary treatment. Treatment with synbiotics increased the frequency of response potentials of the propagated phase III of the MMC at both levels of the jejunum, but not in the duodenum. In both parts of the jejunum, the supplementation of the diet significantly decreased the duration of phase II of the MMC, while it did not change the duration of phase I and phase III. Using the telemetry technique it was demonstrated that changes in the gastrointestinal microflora exhibited an intestinal motility response and, more importantly, that such changes can be initiated by the addition of synbiotics to the diet.<\/jats:p>","DOI":"10.1113\/expphysiol.2005.031708","type":"journal-article","created":{"date-parts":[[2005,11,2]],"date-time":"2005-11-02T01:24:42Z","timestamp":1130894682000},"page":"229-237","source":"Crossref","is-referenced-by-count":39,"title":["Relationship between dietary\u2010induced changes in intestinal commensal microflora and duodenojejunal myoelectric activity monitored by radiotelemetry in the rat <i>in vivo<\/i>"],"prefix":"10.1113","volume":"91","author":[{"given":"V.","family":"Lesniewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. N.","family":"Laerke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.12.5656-5667.2001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2240-2247.2004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.54.703"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944-5013-00192"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1996.524292000.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-121-30944"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.1.130"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.6.G1415"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp010891"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.5.G925"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.11.1953"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367792780745788"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2001.03531.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-445X.2000.00352.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.7.1438S"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90192-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2527\/2005.8371554x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087542"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.3.G368"},{"key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1128\/iai.57.2.559-565.1989","article-title":"Control of Escherichia coli populations by a combination of indigenous clostridia and lactobacilli in gnotobiotic mice and continuous\u2010flow cultures","volume":"57","author":"Itoh K","year":"1989","journal-title":"Infect Immun"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(88)80068-4"},{"key":"e_1_2_5_23_1","first-page":"72","article-title":"The antagonistic activity of bifidobacteria in vitro and in vivo studied by using gnotobiological technology","volume":"5","author":"Korshunov VM","year":"1999","journal-title":"Zh Mikrobiol Epidemiol Immunobiol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00164.2002"},{"key":"e_1_2_5_25_1","first-page":"8","article-title":"The use of radiotelemetry in small laboratory animals: recent advances","volume":"40","author":"Kramer K","year":"2001","journal-title":"Contemp Top Lab Anim Sci"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114599001622"},{"key":"e_1_2_5_27_1","first-page":"347","article-title":"Activity of the gastro\u2010intestinal musculature and movements of digesta","volume":"4","author":"Laplace JP","year":"1979","journal-title":"Ann Rech V\u00e9t"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1017\/S1357729800055363","article-title":"The effect of change of the diet and feeding regimen at weaning on duodenal myoelectrical activity in piglets","volume":"71","author":"Lesniewska V","year":"2000","journal-title":"Anim Sci"},{"key":"e_1_2_5_29_1","first-page":"5","article-title":"Application of radio\u2010telemetry using DSI implants and equipment for gastrointestinal EMG recordings in rats","volume":"3","author":"Lesniewska V","year":"2004","journal-title":"Telemetry Times"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(02)00365-3"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1139\/w01-112"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000101671.49265.cf"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.6.3485-3492.2004"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.8.3391-3395.2001"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199808000-00007"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063075"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.912-920.2005"},{"key":"e_1_2_5_38_1","first-page":"369","article-title":"Eveluation of selective media for bifidobacteria in poultry and rabbit caecal samples","volume":"46","author":"Rada V","year":"1999","journal-title":"Zentralbi Veterinarmed B"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"e_1_2_5_40_1","first-page":"817","volume-title":"Handbook of Physiology","author":"Sarna SK","year":"1989"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90320-1"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252102"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1969.217.6.1757"},{"key":"e_1_2_5_44_1","first-page":"383","volume-title":"Physiology of Gastrointestinal Tract","author":"Szurszewski JH","year":"1987"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.23.1384"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108740"},{"key":"e_1_2_5_47_1","first-page":"299","article-title":"Preliminary investigation of the probiotic potential of Lactobacillus rhamnosus strain GG in horses: fecal recovery following oral administration and safety","volume":"44","author":"Weese JS","year":"2003","journal-title":"Can Vet J"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.10.6113-6122.2004"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015882"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(95)00059-K"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2005.031708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.2005.031708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:40:14Z","timestamp":1696981214000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.2005.031708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,20]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1113\/expphysiol.2005.031708"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2005.031708","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,20]]}}}