{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:25:10Z","timestamp":1697001910253},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T00:00:00Z","timestamp":1143158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>Regional intra\u2010arterial infusion of human placental lactogen in anaesthetized pigs has been shown to cause coronary, renal and iliac vasoconstriction by antagonizing the vasodilatory effects of \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptors. Since nitric oxide is known to modulate or mediate \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic effects, the present study was planned in the same experimental model to determine the role of nitric oxide in the above vascular responses to human placental lactogen. In eight pigs anaesthetized with sodium pentobarbitone, changes in anterior descending coronary, left renal and left internal iliac blood flow caused by intra\u2010arterial infusion of human placental lactogen at constant heart rate and arterial blood pressure were assessed using electromagnetic flowmeters. Intra\u2010arterial infusion of the human placental lactogen caused decreases in coronary, renal and iliac blood flow which, respectively, averaged 16.7, 8.1 and 12.2% of the baseline values. The role of nitric oxide in this response was studied in the same pigs by repeating the experiments, after measured blood flows had returned to baseline values, following intra\u2010arterial administration of <jats:italic>N<\/jats:italic><jats:sup>\u03c9<\/jats:sup>\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine methyl ester (<jats:sc>l<\/jats:sc>\u2010NAME). The subsequent intra\u2010arterial infusion of human placental lactogen did not cause any significant changes in measured blood flows, even when performed after reversing the increase in arterial blood pressure and coronary, renal and iliac resistance caused by <jats:sc>l<\/jats:sc>\u2010NAME with continuous intravenous infusion of papaverine. These results indicate that the coronary, renal and iliac vasoconstriction caused by human placental lactogen, known to involve antagonism of \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic vasodilatory effects, was mediated by inhibition of nitric oxide release.<\/jats:p>","DOI":"10.1113\/expphysiol.2005.032755","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T01:45:05Z","timestamp":1141350305000},"page":"603-610","source":"Crossref","is-referenced-by-count":3,"title":["The role of nitric oxide in the peripheral vasoconstriction caused by human placental lactogen in anaesthetized pigs"],"prefix":"10.1113","volume":"91","author":[{"given":"C.","family":"Molinari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Grossini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A. S. 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