{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:58:12Z","timestamp":1789408692239,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,20]],"date-time":"2006-06-20T00:00:00Z","timestamp":1150761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>The purpose of this study was to compare the kinetics of estimated capillary blood flow \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu1.gif\" xlink:title=\"inline image\"\/> to those of femoral artery blood flow \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu2.gif\" xlink:title=\"inline image\"\/> and estimated muscle oxygen uptake \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu3.gif\" xlink:title=\"inline image\"\/>. Nine healthy subjects performed a series of transitions from rest to moderate (below estimated lactate threshold, 6 min bouts) knee extension exercise. Pulmonary oxygen uptake \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu4.gif\" xlink:title=\"inline image\"\/> was measured breath by breath, \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu5.gif\" xlink:title=\"inline image\"\/> was measured continuously using Doppler ultrasound, and deoxyhaemoglobin ([HHb]) was estimated by near\u2010infrared spectroscopy over the rectus femoris throughout the tests. The time course of \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu6.gif\" xlink:title=\"inline image\"\/> was estimated by rearranging the Fick equation (i.e. \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu7.gif\" xlink:title=\"inline image\"\/>), (arterio \u2013 venous O<jats:sub>2<\/jats:sub> difference) using the primary component of \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu8.gif\" xlink:title=\"inline image\"\/> to represent \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu9.gif\" xlink:title=\"inline image\"\/> and [HHb] as a surrogate for <jats:styled-content>(<jats:italic>a<\/jats:italic>\u2212<jats:italic>v<\/jats:italic>)O<jats:sub>2<\/jats:sub><\/jats:styled-content>. The overall kinetics of \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu10.gif\" xlink:title=\"inline image\"\/> (mean response time, MRT, 13.7 \u00b1 7.0 s), \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu11.gif\" xlink:title=\"inline image\"\/> (\u03c4, 27.8 \u00b1 9.0 s) and \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu12.gif\" xlink:title=\"inline image\"\/> (MRT, 41.4 \u00b1 19.0 s) were significantly (<jats:italic>P<\/jats:italic> &lt; 0.05) different from each other. We conclude that for moderate intensity knee extension exercise, conduit artery blood flow \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu13.gif\" xlink:title=\"inline image\"\/> kinetics may not be a reasonable approximation of blood flow kinetics in the microcirculation \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/EPH_260_mu14.gif\" xlink:title=\"inline image\"\/>, the site of gas exchange. This temporal dissociation suggests that blood flow may be controlled differently at the conduit artery level than in the microcirculation.<\/jats:p>","DOI":"10.1113\/expphysiol.2005.032904","type":"journal-article","created":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T01:34:00Z","timestamp":1143164040000},"page":"661-671","source":"Crossref","is-referenced-by-count":83,"title":["Human femoral artery and estimated muscle capillary blood flow kinetics following the onset of exercise"],"prefix":"10.1113","volume":"91","author":[{"given":"Allison J.","family":"Harper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo F.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Lutjemeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana 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