{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T02:40:03Z","timestamp":1736390403237,"version":"3.32.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T00:00:00Z","timestamp":1156118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>The purpose of the present study was to determine the cardiovascular effects of the \u03ba\u2010opioid receptor agonist U\u201050488H at two stages of postnatal maturation under physiological conditions. Experiments were carried out firstly to define systemic and renal haemodynamic responses to \u03ba\u2010opioid receptor activation and, secondly, to determine whether these effects are altered during postnatal maturation. To investigate whether the responses to U\u201050488H resulted from receptor\u2010dependent effects, responses to U\u201050488H were also tested in the presence of the specific \u03ba\u2010opioid receptor antagonist 5\u2032\u2010guanidinonaltrindole (GNTI). Experiments were carried out in two groups of conscious, chronically instrumented lambs aged \u223c1 and \u223c6 weeks. Mean arterial pressure, mean venous pressure and renal blood flow (RBF) were measured for 30 min before and 90 min after i.v. injection of U\u201050488H or vehicle. Heart rate increased in both age groups of lambs within 10 min of U\u201050488H administration. Mean arterial pressure decreased for 50 min following U\u201050488H administration at 1 week but, in contrast, increased transiently at 10 min in 6\u2010week\u2010old lambs, returning to control levels by 20 min. In both age groups, there was a sustained decrease in RBF following U\u201050488H. The aforementioned responses to U\u201050488H were abolished by pretreatment with GNTI. These data provide the first measurements of systemic and renal haemodynamic responses to \u03ba\u2010opioid receptor activation during postnatal maturation.<\/jats:p>","DOI":"10.1113\/expphysiol.2006.033456","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:36:46Z","timestamp":1148603806000},"page":"877-885","source":"Crossref","is-referenced-by-count":4,"title":["Modulation of systemic and renal haemodynamics by \u03ba\u2010opioids in conscious lambs"],"prefix":"10.1113","volume":"91","author":[{"given":"Wei","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine G.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb14976.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(89)90067-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111918"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/y97-039"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245071"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0022-3565(24)37419-1","article-title":"Kappa\u2010opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception","volume":"285","author":"Butelman ER","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015829"},{"key":"e_1_2_5_9_1","first-page":"461","article-title":"Kappa opiate receptor multiplicity: evidence for two U50,488\u2010sensitive kappa 1 subtypes and a novel kappa 3 subtype","volume":"251","author":"Clark JA","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198708000-00007"},{"key":"e_1_2_5_11_1","first-page":"30","article-title":"Nor\u2010binaltorphimine: a potent and selective \u03ba\u2010opioid receptor antagonist with long\u2010lasting activity in vivo","volume":"316","author":"Endoh T","year":"1992","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(84)90086-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.959823"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.076828"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90328-7"},{"key":"e_1_2_5_16_1","first-page":"409","article-title":"Cardiovascular depressant effects of the kappa opioid receptor agonists U50488H and spiradoline mesylate","volume":"26","author":"Hall ED","year":"1988","journal-title":"Circ Shock"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02624-5"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00208-9"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb02324.x"},{"key":"e_1_2_5_20_1","first-page":"230","article-title":"Role of renal nerves in excretory responses to administration of kappa agonists in conscious spontaneously hypertensive rats","volume":"251","author":"Kapusta DR","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08441.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-2-337"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(87)90226-4"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90132-1"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00014-3"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00464-5"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90093-8"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1038-x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80923-I"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(81)90057-3"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)91150-7"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb04133.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043383917"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(90)90088-M"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90025-B"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-015"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-03-00584.1985"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0000665"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(86)90096-9"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00421-9"},{"key":"e_1_2_5_41_1","first-page":"349","article-title":"Ontogenesis of opiate receptors in regions of the ovine brain","volume":"2","author":"Villiger JW","year":"1982","journal-title":"Pediatr Pharmacol"},{"key":"e_1_2_5_42_1","first-page":"7","article-title":"U\u201050,488: a selective and structurally novel non\u2010mu (kappa) opioid agonist","volume":"224","author":"Vonvoigtlander PF","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90451-8"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(95)00075-O"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1020"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2006.033456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2006.033456","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.2006.033456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T02:15:56Z","timestamp":1736388956000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.2006.033456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,21]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1113\/expphysiol.2006.033456"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2006.033456","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"type":"print","value":"0958-0670"},{"type":"electronic","value":"1469-445X"}],"subject":[],"published":{"date-parts":[[2006,8,21]]}}}