{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:21:14Z","timestamp":1791228074119,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T00:00:00Z","timestamp":1168560000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Patients with recurrent apnoeas exhibit autonomic abnormalities manifested as persistent increase in sympathetic nerve activity (SNA). Several studies suggest that chronic intermittent hypoxia (CIH) resulting from recurrent apnoeas is a major stimulus for evoking autonomic morbidity. Although it has been proposed that CIH, by way of activating the chemoreceptor reflex, leads to sympathetic excitation, the underlying mechanisms are incompletely understood. Studies on experimental models have provided new insights into the mechanisms associated with CIH\u2010evoked sympathoexcitation. The purpose of this article is to highlight recent information on systemic, cellular and molecular analysis of the effects of CIH on chemoreceptor\u2010mediated sympathoexcitation. Chronic intermittent hypoxia exerts two major effects on the chemoreceptor reflex: (a) augmentation of the carotid body and sympathetic effector responses to acute hypoxia; and (b) induction of long\u2010lasting activation of both the sensor and the effector that persists several hours after termination of CIH. Available evidence indicates that CIH may facilitate processing of chemoreceptor afferent information at the central nervous system. Recent studies suggest that reactive oxygen species\u2010mediated signalling is a major cellular mechanism, and transcriptional activation by hypoxia\u2010inducible factor\u20101 is one of the critical molecular mechanisms underlying chemoreceptor\u2010mediated sympathoexcitation by CIH.<\/jats:p>","DOI":"10.1113\/expphysiol.2006.036434","type":"journal-article","created":{"date-parts":[[2006,11,24]],"date-time":"2006-11-24T01:34:44Z","timestamp":1164332084000},"page":"39-44","source":"Crossref","is-referenced-by-count":95,"title":["Systemic, cellular and molecular analysis of chemoreflex\u2010mediated sympathoexcitation by chronic intermittent hypoxia"],"prefix":"10.1113","volume":"92","author":[{"given":"Nanduri R.","family":"Prabhakar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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