{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T02:10:32Z","timestamp":1771899032557,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T00:00:00Z","timestamp":1183420800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>We tested the hypothesis that oleic acid\u2010induced acute lung injury activates pulmonary nociceptors, that is, C fibre receptors (CFRs) and high\u2010threshold A\u03b4 fibre receptors (HTARs). Single\u2010unit activity was recorded in the cervical vagus nerve and assessed before and after injecting oleic acid (75 \u03bcl kg<jats:sup>\u22121<\/jats:sup><jats:sc>i.v.<\/jats:sc>) into anaesthetized, open\u2010chest, mechanically ventilated rabbits. Unit activities increased within seconds and peaked within a few minutes (from 0.3 \u00b1 0.1 to 1.4 \u00b1 0.9 impulses s<jats:sup>\u22121<\/jats:sup> for CFRs and from 0.5 \u00b1 0.1 to 1.7 \u00b1 0.3 impulses s<jats:sup>\u22121<\/jats:sup> for HTARs, both <jats:italic>n<\/jats:italic>= 8 and <jats:italic>P<\/jats:italic> &lt; 0.05). These activities were sustained while pulmonary oedema developed and dynamic lung compliance decreased over the 90 min observation period. Activities in slowly adapting receptors and rapidly adapting receptors were also increased; however, their responsiveness to airway pressure stimulation decreased progressively. We conclude that pulmonary nociceptors are stimulated during acute lung injury. The dual nociceptor system, consisting of both non\u2010myelinated CFRs and myelinated HTARs, may play an important role in the pathophysiological process of acute lung injury\u2010induced respiratory responses.<\/jats:p>","DOI":"10.1113\/expphysiol.2006.036673","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T00:33:06Z","timestamp":1175128386000},"page":"749-755","source":"Crossref","is-referenced-by-count":48,"title":["Behaviours of pulmonary sensory receptors during development of acute lung injury in the rabbit"],"prefix":"10.1113","volume":"92","author":[{"given":"Shuxin","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.03.001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(77)90086-X"},{"key":"e_1_2_5_6_1","first-page":"395","volume-title":"Handbook of Physiology, section 3, The Respiratory System, vol II, Control of Breathing","author":"Coleridge HM","year":"1986"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1152\/ajplegacy.1958.196.1.49","article-title":"Effect of pulmonary congestion on vagal afferent activity","volume":"196","author":"Costantin LL","year":"1959","journal-title":"Am J Physiol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.6.L1091"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9812042"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00490-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1152\/jappl.1990.69.3.1143","article-title":"Altered function of pulmonary surfactant in fatty acid lung injury","volume":"69","author":"Hall SB","year":"1990","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018377"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00241-9"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1683-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357023150"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00100.2006"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016869"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90019-S"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01507-2"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00539.2004"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00204-8"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7944(02)00775-4"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9808101"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F305"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1973.53.1.159"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(86)90058-7"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.4.512"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111590"},{"key":"e_1_2_5_29_1","first-page":"171","article-title":"Role of arachidonic acid metabolites in oleic acid induced pulmonary injury in a canine model. 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