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Thus, the purpose of the present study was to determine whether there are any changes in Hsp25, pHsp25 and caspase\u20103 activity among rat muscles having different fibre type compositions and functions [soleus, adductor longus (AL), plantaris and tibialis anterior (TA)] at 0 (control), 1, 8 or 28 days after a complete spinal cord transection (ST). The Hsp25 levels were unaffected on days 1 and 8 in all muscles, except for a significant reduction on day 8 in plantaris. The Hsp25 levels were lower than control values in all muscles except TA on day 28. The pHsp25 levels were lower than control values after 8 and 28 days in plantaris and AL and after 28 days in soleus, but higher than control in TA after 8 and 28 days. Caspase\u20103 activity was higher in ST than control rats on day 8 in all muscles except TA. Caspase\u20103 activity was negatively correlated with muscle mass for all muscles. In plantaris, Hsp25 and pHsp25 were negatively correlated with caspase\u20103 activity and Hsp25 was correlated with muscle mass. These relationships were not observed in other muscles. Thus, the effects of ST on Hsp25 and caspase\u20103 are muscle specific and time dependent, factors that should be considered in developing any intervention to maintain muscle mass after a spinal cord injury.<\/jats:p>","DOI":"10.1113\/expphysiol.2007.041228","type":"journal-article","created":{"date-parts":[[2007,12,22]],"date-time":"2007-12-22T01:33:48Z","timestamp":1198287228000},"page":"415-425","source":"Crossref","is-referenced-by-count":14,"title":["Time\u2010dependent changes in caspase\u20103 activity and heat shock protein 25 after spinal cord transection in adult rats"],"prefix":"10.1113","volume":"93","author":[{"given":"Kimberly A.","family":"Huey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland 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