{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:28:53Z","timestamp":1773458933010,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T00:00:00Z","timestamp":1218672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>This study aimed to quantify the effect of cardiac hypertrophy induced with isoprenaline and caffeine on reflex regulation of renal sympathetic nerve activity by the arterial and cardiopulmonary baroreceptors. Male Wistar rats, untreated or given water containing caffeine and subcutaneous (<jats:sc>s.c.<\/jats:sc>) isoprenaline every 72 h for 2 weeks or thyroxine <jats:sc>s.c.<\/jats:sc> for 7 days, were anaesthetized and prepared for measurement of renal sympathetic nerve activity or cardiac indices. Both isoprenaline\u2013caffeine and thyroxine treatment blunted weight gain but increased heart weight and heart weight to body weight ratio by 40 and 14% (both <jats:italic>P<\/jats:italic> &lt; 0.01), respectively. In the isoprenaline\u2013caffeine group, the maximal rate of change of left ventricular pressure and the contractility index were higher by 17 and 14% (both <jats:italic>P<\/jats:italic> &lt; 0.01), respectively, compared with untreated rats. In the isoprenaline\u2013caffeine\u2010treated rats, baroreflex gain curve sensitivity was depressed by approximately 30% (<jats:italic>P<\/jats:italic> &lt; 0\/05), while the mid\u2010point blood pressure was lower, by 15% (<jats:italic>P<\/jats:italic> &lt; 0\/05), and the range of the curve was 60% (<jats:italic>P<\/jats:italic> &lt; 0.05) greater than in the untreated rats. An acute intravenous infusion of a saline load decreased renal sympathetic nerve activity by 42% (<jats:italic>P<\/jats:italic> &lt; 0.05) in the untreated rats but had no effect in the isoprenaline\u2013caffeine\u2010 or the thyroxine\u2010treated groups. The isoprenaline\u2013caffeine treatment induced cardiac hypertrophy with raised cardiac performance and an associated depression in the reflex regulation of renal sympathetic nerve activity by both high\u2010 and low\u2010pressure baroreceptors. The thyroxine\u2010induced cardiac hypertrophy also blunted the low\u2010pressure baroreceptor\u2010mediated renal sympatho\u2010inhibition. These findings demonstrate that in cardiac hypertrophy without impaired cardiac function, there is a blunted baroreceptor control of renal sympathetic outflow.<\/jats:p>","DOI":"10.1113\/expphysiol.2008.043216","type":"journal-article","created":{"date-parts":[[2008,5,17]],"date-time":"2008-05-17T00:45:07Z","timestamp":1210985107000},"page":"1058-1064","source":"Crossref","is-referenced-by-count":19,"title":["Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats"],"prefix":"10.1113","volume":"93","author":[{"given":"Evelyn T.","family":"Flanagan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire 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