{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:11:20Z","timestamp":1773249080097,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T00:00:00Z","timestamp":1231977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>Skeletal muscles play key roles in the development of various pathologies, including bronchial asthma and several types of auto\u2010immune disorders, e.g. polymyositis. Since most of these maladies have an immunological\/allergic element, this paper is devoted to assessing the impact of immunobiological reorganization on the functional properties of isolated skeletal muscles in mice. A combination of two methods (myography and electrophysiology) was used to evaluate extensor digitorum longus (EDL) and diaphragmatic muscle (DM) in this regard. Conventional myographic technique showed that ovalbumin\u2010induced sensitization (OS) produced different changes in the contractile properties of EDL and DM. The amplitudes of carbachol (CCh)\u2010induced contractions increased in DM but decreased in EDL. Those changes were inversely related to OS\u2010mediated changes of non\u2010quantal acetylcholine (ACh) release intensity within the muscle endplate, as shown by the electrophysiologically measured H\u2010effect. These results clearly show that OS\u2010mediated changes of non\u2010quantal ACh release alter the functional properties of postjunctional ACh receptors and therefore contribute to the disturbance of CCh\u2010induced contractility of skeletal muscles. Other mechanisms of OS\u2010mediated changes of skeletal muscle contractility are also proposed and discussed.<\/jats:p>","DOI":"10.1113\/expphysiol.2008.045740","type":"journal-article","created":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T01:54:24Z","timestamp":1228528464000},"page":"264-268","source":"Crossref","is-referenced-by-count":11,"title":["Ovalbumin\u2010induced sensitization affects non\u2010quantal acetylcholine release from motor nerve terminals and alters contractility of skeletal muscles in mice"],"prefix":"10.1113","volume":"94","author":[{"given":"Alexander Y.","family":"Teplov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey N.","family":"Grishin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marat A.","family":"Mukhamedyarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Airat 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