{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:57:54Z","timestamp":1793145474390,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T00:00:00Z","timestamp":1245024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>\n                    Sympathetic outflow is increased in hypertension. The aim of the present study was to investigate whether the cardiac sympathetic afferent reflex (CSAR) is enhanced in two\u2010kidney one\u2010clip (2K1C) renovascular hypertensive rats, and whether the enhanced CSAR contributes, in part, to the increased sympathetic outflow. Furthermore, the role of central angiotensin II type 1 (AT\n                    <jats:sub>1<\/jats:sub>\n                    ) receptors in mediating the CSAR was determined. Under urethane and \u03b1\u2010chloralose anaesthesia, the renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded in sinoaortic denervated and cervical vagotomized rats. The CSAR was evaluated by the response of RSNA and MAP to epicardial application of 1.0 nmol of capsaicin. Compared with sham\u2010operated rats, the CSAR, baseline RSNA and plasma noradrenaline level were significantly enhanced in 2K1C rats. Intrapericardial administration of resiniferatoxin, which abolishes the CSAR because of the desensitization of transient receptor potential vanilloid 1\u2010containing cardiac afferent fibres, decreased the RSNA and MAP. The enhanced CSAR in 2K1C rats was normalized by intracerebroventricular administration of the AT\n                    <jats:sub>1<\/jats:sub>\n                    receptor antagonist losartan. Intracerebroventricular administration of angiotensin II further potentiated the enhanced CSAR in 2K1C rats, a response which was abolished by pretreatment with losartan. These results indicate that the CSAR is enhanced in 2K1C rats and the enhanced CSAR contributes, in part, to the sympathetic activation and hypertension. Central AT\n                    <jats:sub>1<\/jats:sub>\n                    receptors are involved in the enhanced CSAR in 2K1C rats.\n                  <\/jats:p>","DOI":"10.1113\/expphysiol.2008.046565","type":"journal-article","created":{"date-parts":[[2009,4,3]],"date-time":"2009-04-03T21:50:30Z","timestamp":1238795430000},"page":"785-794","source":"Crossref","is-referenced-by-count":52,"title":["Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive 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