{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:43:33Z","timestamp":1773420213044,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T00:00:00Z","timestamp":1236816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>This work was undertaken to study the effect of pectin feeding on the expression level, cellular localization and functional activity of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of rats. The results indicated that MCT1 protein level was significantly increased along the entire length of the gastrointestinal tract of pectin\u2010fed rats in comparison with control animals. Immunohistochemical analysis revealed an increase in MCT1 in the stratified squamous epithelia of the forestomach as well as in the basolateral membranes of the cells lining the gastric pit of the glandular stomach of pectin\u2010fed rats when compared with control animals. The parietal cells, which showed barely any or no detectable MCT1 in the control group, exhibited a strong intensity of MCT1 on the basolateral membranes in pectin\u2010fed rats. In the small intestine of pectin\u2010fed rats, strong immunopositivity for MCT1 was detected in the brush border and basolateral membranes of the absorptive enterocytes lining the entire villi, while in control rats, weak reactivity was detected on the brush border membrane in a few absorptive enterocytes in the villus tip. In the large intestine of control animals, MCT1 was detected on the basolateral membranes of the epithelia lining the caecum and colon. This staining intensity was markedly increased in pectin\u2010fed rats, along with the appearance of strong reactivity for MCT1 on the apical membranes of the surface and crypt epithelia of caecum and colon. Our results also showed that MCT1 co\u2010localizes with its chaperone, basigin (CD147), in the rat gastrointestinal tract, and that the pectin feeding increased the expression of CD147. <jats:italic>In vivo<\/jats:italic> functional studies revealed an enhanced acetate absorption in the colon of pectin\u2010fed in comparison with control animals. We conclude that MCT1 is up\u2010regulated along the gastrointestinal tract of pectin\u2010fed rats, which might represent an adaptive response to the increased availability of its substrates.<\/jats:p>","DOI":"10.1113\/expphysiol.2009.046797","type":"journal-article","created":{"date-parts":[[2009,1,24]],"date-time":"2009-01-24T01:26:15Z","timestamp":1232760375000},"page":"422-433","source":"Crossref","is-referenced-by-count":31,"title":["Dietary pectin up\u2010regulates monocaboxylate transporter 1 in the rat gastrointestinal tract"],"prefix":"10.1113","volume":"94","author":[{"given":"Doaa","family":"Kirat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsu","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiyu","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719902300518"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740630405"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.46.030184.002113"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1990.70.2.567"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(87)90433-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000199821"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90601-7"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.014241"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00384345"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1994.tb09758.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00172.2003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(99)00111-4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069705"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.4.1843"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-8600(02)80002-5"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1067-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015014829605"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.27.243"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2005.07.005"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.033837"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.115931"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.15.3896"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(00)00102-9"},{"key":"e_1_2_5_25_1","volume-title":"Dietary Fiber: Its Surprising Range of Therapeutic and Protective Health Benefits","author":"Lorenzani SS","year":"1998"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.9.1522"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20320"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0552"},{"key":"e_1_2_5_29_1","first-page":"39","article-title":"Partition and absorption of volatile fatty acids in the alimentary canal of the rat","volume":"7","author":"R\u00e9m\u00e9sy C","year":"1976","journal-title":"Ann Rech V\u00e9t"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.719ba.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.20.91"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19870073"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04706.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2270223"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1958.sp005955"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991776804"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.2.170"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2009.046797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2009.046797","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.2009.046797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:38:41Z","timestamp":1697308721000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.2009.046797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,12]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1113\/expphysiol.2009.046797"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2009.046797","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,12]]}}}