{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:24:48Z","timestamp":1769811888423,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p><jats:bold>The ciliary beat frequency (CBF) of guinea\u2010pig fimbria during the ovarian cycle was measured by video microscopy using a high\u2010speed camera (500 Hz). In the follicular phase, with increasing concentrations of \u03b2\u2010oestradiol ([\u03b2E<jats:sub>2<\/jats:sub>]) and a low concentration of progesterone ([PRG]), CBF increased from 13.5 to 16 Hz. In the ovulatory phase, with further increase of [\u03b2E<jats:sub>2<\/jats:sub>], CBF decreased gradually from 16 to 13.5 Hz. In the early luteal phase, with low [PRG] and [\u03b2E<jats:sub>2<\/jats:sub>], CBF increased to \u223c17 Hz; however, in the middle luteal phase, with increasing [PRG], CBF decreased (\u223c12 Hz), and in the late luteal phase, with decreasing [PRG], CBF increased to \u223c15 Hz. Then, in the resting phase, with low [\u03b2E<jats:sub>2<\/jats:sub>] and [PRG], CBF decreased immediately to \u223c14 Hz. The CBF of the fimbria was measured in guinea\u2010pigs treated with \u03b2\u2010oestradiol benzoate (\u03b2E<jats:sub>2<\/jats:sub>B) or medroxyprogesterone (mPRG). A low dose of \u03b2E<jats:sub>2<\/jats:sub>B increased CBF to \u223c14.5 Hz, whereas a high dose decreased it to \u223c11 Hz. A \u03b2E<jats:sub>2<\/jats:sub> receptor blocker, ICI\u2010182,780, abolished the \u03b2E<jats:sub>2<\/jats:sub>B\u2010induced CBF changes and maintained CBF at \u223c12.0 Hz. Medroxyprogesterone decreased CBF to \u223c12.5 Hz, and mifepristone (a PRG receptor blocker) abolished the mPRG\u2010induced CBF decrease and maintained CBF at \u223c15 Hz. The addition of both blockers increased CBF to \u223c18 Hz, suggesting that activation of \u03b2E<jats:sub>2<\/jats:sub> or PRG receptors decreases the CBF of the fimbria. In conclusion, a moderate [\u03b2E<jats:sub>2<\/jats:sub>] increase maintains a high CBF (15.5 Hz) in the follicular phase, and then further [\u03b2E<jats:sub>2<\/jats:sub>] increase decreases CBF to 13.5 Hz in the ovulatory phase. In the early and late luteal phase, low [\u03b2E<jats:sub>2<\/jats:sub>] and [PRG] increase CBF to 17 and 15 Hz, respectively, and in the middle luteal phase a high [PRG] decreases CBF (to \u223c12 Hz). Thus, the CBF of the fimbria was controlled by signals via \u03b2E<jats:sub>2<\/jats:sub> and PRG receptors in guinea\u2010pigs.<\/jats:bold><\/jats:p>","DOI":"10.1113\/expphysiol.2010.052555","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T02:09:45Z","timestamp":1270174185000},"page":"819-828","source":"Crossref","is-referenced-by-count":31,"title":["Ciliary beat frequency controlled by oestradiol and progesterone during ovarian cycle in guinea\u2010pig Fallopian 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