{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:23:31Z","timestamp":1790342611406,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T00:00:00Z","timestamp":1297036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T00:00:00Z","timestamp":1297036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"DOI":"10.1113\/expphysiol.2010.055848","type":"journal-article","created":{"date-parts":[[2011,1,15]],"date-time":"2011-01-15T01:49:44Z","timestamp":1295056184000},"page":"451-459","source":"Crossref","is-referenced-by-count":45,"title":["Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (<i>Kcnj16<\/i>)"],"prefix":"10.1113","volume":"96","author":[{"given":"Stefan","family":"Trapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Gourine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,7]]},"reference":[{"key":"10.1113\/expphysiol.2010.055848-BIB1|cit1","first-page":"183","article-title":"Cloning and expression of a family of inward rectifier potassium channels","volume":"2","author":"Bond","year":"1994","journal-title":"Receptors Channels"},{"key":"10.1113\/expphysiol.2010.055848-BIB2|cit2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1074\/jbc.M110.189290","article-title":"Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2\/pH sensitivity","volume":"286","author":"D\u2019Adamo","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1113\/expphysiol.2010.055848-BIB3|cit3","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1002\/j.1460-2075.1996.tb00784.x","article-title":"Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH","volume":"15","author":"Fakler","year":"1996","journal-title":"EMBO J"},{"key":"10.1113\/expphysiol.2010.055848-BIB4|cit4","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0910059107","article-title":"TASK2 potassium channels set central respiratory CO2 and O2 sensitivity","volume":"107","author":"Gestreau","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1113\/expphysiol.2010.055848-BIB5|cit5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.1190721","article-title":"Astrocytes control breathing through pH-dependent release of ATP","volume":"329","author":"Gourine","year":"2010","journal-title":"Science"},{"key":"10.1113\/expphysiol.2010.055848-BIB6|cit6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0034-5687(79)90082-3","article-title":"Relative contribution of central and peripheral chemoreceptors to the ventilatory response to CO2 during hyperoxia","volume":"37","author":"Heeringa","year":"1979","journal-title":"Respir Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB7|cit7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1152\/physrev.00021.2009","article-title":"Inwardly rectifying potassium channels: their structure, function, and physiological roles","volume":"90","author":"Hibino","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1113\/expphysiol.2010.055848-BIB8|cit8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0034-5687(01)00301-2","article-title":"An alternative approach to the identification of respiratory central chemoreceptors in the brainstem","volume":"129","author":"Jiang","year":"2001","journal-title":"Respir Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB9|cit9","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1523\/JNEUROSCI.20-15-05733.2000","article-title":"Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina","volume":"20","author":"Kofuji","year":"2000","journal-title":"J Neurosci"},{"key":"10.1113\/expphysiol.2010.055848-BIB10|cit10","doi-asserted-by":"crossref","first-page":"F1398","DOI":"10.1152\/ajprenal.00288.2007","article-title":"Kir4.1\/Kir5.1 channel forms the major K+ channel in the basolateral membrane of mouse renal collecting duct principal cells","volume":"294","author":"Lachheb","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB11|cit11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1113\/jphysiol.2001.012961","article-title":"An inward rectifier K+ channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels","volume":"538","author":"Lourdel","year":"2002","journal-title":"J Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/nn1357","article-title":"Respiratory control by ventral surface chemoreceptor neurons in rats","volume":"7","author":"Mulkey","year":"2004","journal-title":"Nature Neurosci"},{"key":"10.1113\/expphysiol.2010.055848-BIB13|cit13","doi-asserted-by":"crossref","first-page":"14049","DOI":"10.1523\/JNEUROSCI.4254-07.2007","article-title":"TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity","volume":"27","author":"Mulkey","year":"2007","journal-title":"J Neurosci"},{"key":"10.1113\/expphysiol.2010.055848-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1152\/japplphysiol.00112.2008","article-title":"Central chemoreception is a complex system function that involves multiple brain stem sites","volume":"106","author":"Nattie","year":"2009","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB15|cit15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0165-0270(95)00147-6","article-title":"A working heart-brainstem preparation of the mouse","volume":"65","author":"Paton","year":"1996","journal-title":"J Neurosci Methods"},{"key":"10.1113\/expphysiol.2010.055848-BIB16|cit16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1469-7793.1999.639ad.x","article-title":"Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver","volume":"514","author":"Pearson","year":"1999","journal-title":"J Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB17|cit17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1469-7793.2001.0359f.x","article-title":"Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1","volume":"532","author":"Pessia","year":"2001","journal-title":"J Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB18|cit18","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1002\/j.1460-2075.1996.tb00661.x","article-title":"Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels","volume":"15","author":"Pessia","year":"1996","journal-title":"EMBO J"},{"key":"10.1113\/expphysiol.2010.055848-BIB19|cit19","doi-asserted-by":"crossref","first-page":"11315","DOI":"10.1523\/JNEUROSCI.23-36-11315.2003","article-title":"Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia","volume":"23","author":"Rong","year":"2003","journal-title":"J Neurosci"},{"key":"10.1113\/expphysiol.2010.055848-BIB20|cit20","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1523\/JNEUROSCI.1810-08.2008","article-title":"A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing","volume":"28","author":"Trapp","year":"2008","journal-title":"J Neurosci"},{"key":"10.1113\/expphysiol.2010.055848-BIB21|cit21","doi-asserted-by":"crossref","first-page":"16404","DOI":"10.1074\/jbc.C000127200","article-title":"pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia","volume":"275","author":"Tucker","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1113\/expphysiol.2010.055848-BIB22|cit22","doi-asserted-by":"crossref","first-page":"8215","DOI":"10.1073\/pnas.0400081101","article-title":"Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport","volume":"101","author":"Warth","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1113\/expphysiol.2010.055848-BIB23|cit23","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1152\/jn.00544.2010","article-title":"Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism","volume":"104","author":"Wenker","year":"2010","journal-title":"J Neurophysiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB24|cit24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00232-004-0652-4","article-title":"Expression and coexpression of CO2-sensitive Kir channels in brainstem neurons of rats","volume":"197","author":"Wu","year":"2004","journal-title":"J Membr Biol"},{"key":"10.1113\/expphysiol.2010.055848-BIB25|cit25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1469-7793.2000.00725.x","article-title":"Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis","volume":"524","author":"Xu","year":"2000","journal-title":"J Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB26|cit26","first-page":"799","article-title":"Expression of inwardly rectifying K+ channels in the carotid body of rat","volume":"23","author":"Yamamoto","year":"2008a","journal-title":"Histol Histopathol"},{"key":"10.1113\/expphysiol.2010.055848-BIB27|cit27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1292\/jvms.70.265","article-title":"Immunohistochemical distribution of inwardly rectifying K+ channels in the medulla oblongata of the rat","volume":"70","author":"Yamamoto","year":"2008b","journal-title":"J Vet Med Sci"},{"key":"10.1113\/expphysiol.2010.055848-BIB28|cit28","doi-asserted-by":"crossref","first-page":"C635","DOI":"10.1152\/ajpcell.00442.2009","article-title":"Intrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice","volume":"298","author":"Zhang","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1113\/expphysiol.2010.055848-BIB29|cit29","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1469-7793.1999.0699u.x","article-title":"Effects of intra- and extracellular acidifications on single channel Kir2.3 currents","volume":"516","author":"Zhu","year":"1999","journal-title":"J Physiol"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2010.055848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2010.055848","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1113\/expphysiol.2010.055848\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T19:55:01Z","timestamp":1626810901000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1113\/expphysiol.2010.055848"}},"subtitle":["Kir5.1 and chemosensory control of breathing"],"short-title":[],"issued":{"date-parts":[[2011,2,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4,1]]}},"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2010.055848","archive":["Portico"],"relation":{},"ISSN":["0958-0670"],"issn-type":[{"value":"0958-0670","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2,7]]}}}