{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:16:08Z","timestamp":1773951368388,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T00:00:00Z","timestamp":1313971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T00:00:00Z","timestamp":1313971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1113\/expphysiol.2011.058511","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T04:00:23Z","timestamp":1309752023000},"page":"1000-1009","source":"Crossref","is-referenced-by-count":16,"title":["Endothelial function after 10 days of bed rest in individuals at risk for type 2 diabetes and cardiovascular disease"],"prefix":"10.1113","volume":"96","author":[{"given":"Mette P.","family":"Sonne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"H\u00f8jbjerre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amra C.","family":"Alibegovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars B.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Stallknecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan A.","family":"Vaag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Dela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,22]]},"reference":[{"key":"10.1113\/expphysiol.2011.058511-BIB1|cit1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/HJR.0b013e3280c284c5","article-title":"Influence of time spent on TV viewing and vigorous intensity physical activity on cardiovascular biomarkers. The Inter 99 study","volume":"14","author":"Aadahl","year":"2007","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1113\/expphysiol.2011.058511-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1152\/jappl.1998.84.4.1365","article-title":"Effects of short-term inactivity on glucose tolerance, energy expenditure, and blood flow in trained subjects","volume":"84","author":"Arciero","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1161\/01.CIR.101.15.1780","article-title":"Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance","volume":"101","author":"Balletshofer","year":"2000","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB4|cit4","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993a","journal-title":"Lancet"},{"key":"10.1113\/expphysiol.2011.058511-BIB5|cit5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF00399095","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth","volume":"36","author":"Barker","year":"1993b","journal-title":"Diabetologia"},{"key":"10.1113\/expphysiol.2011.058511-BIB6|cit6","doi-asserted-by":"crossref","first-page":"H1747","DOI":"10.1152\/ajpheart.00966.2004","article-title":"Vascular adaptation to 4 wk of deconditioning by unilateral lower limb suspension","volume":"288","author":"Bleeker","year":"2005a","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1152\/japplphysiol.00118.2005","article-title":"Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study","volume":"99","author":"Bleeker","year":"2005b","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB8|cit8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/01.mco.0000222097.90890.c2","article-title":"Nutritive blood flow as an essential element supporting muscle anabolism","volume":"9","author":"Clark","year":"2006","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1113\/expphysiol.2011.058511-BIB9|cit9","doi-asserted-by":"crossref","first-page":"E241","DOI":"10.1152\/ajpendo.00408.2002","article-title":"Blood flow and muscle metabolism: a focus on insulin action","volume":"284","author":"Clark","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1113\/expphysiol.2011.058511-BIB10|cit10","doi-asserted-by":"crossref","first-page":"H374","DOI":"10.1152\/ajpheart.00958.2003","article-title":"Preserved flow-mediated dilation in the inactive legs of spinal cord-injured individuals","volume":"287","author":"de Groot","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB11|cit11","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/01.CIR.102.12.1351","article-title":"Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men","volume":"102","author":"DeSouza","year":"2000","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB12|cit12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/CIRCULATIONAHA.109.894824","article-title":"Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)","volume":"121","author":"Dunstan","year":"2010","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB13|cit13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/bmj.318.7181.427","article-title":"Catch-up growth in childhood and death from coronary heart disease: longitudinal study","volume":"318","author":"Eriksson","year":"1999","journal-title":"BMJ"},{"key":"10.1113\/expphysiol.2011.058511-BIB14|cit14","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.1067\/mhj.2003.30","article-title":"Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotion","volume":"145","author":"Gielen","year":"2003","journal-title":"Am Heart J"},{"key":"10.1113\/expphysiol.2011.058511-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1152\/jappl.1994.77.4.1829","article-title":"Modification of forearm resistance vessels by exercise training in young men","volume":"77","author":"Green","year":"1994","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB16|cit16","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1152\/jappl.1996.81.2.943","article-title":"Endothelium-derived nitric oxide activity in forearm vessels of tennis players","volume":"81","author":"Green","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2004.068197","article-title":"Effect of exercise training on endothelium-derived nitric oxide function in humans","volume":"561","author":"Green","year":"2004","journal-title":"J Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB18|cit18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM199807233390404","article-title":"Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction","volume":"339","author":"Haffner","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1113\/expphysiol.2011.058511-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/bmj.303.6809.1019","article-title":"Fetal and infant growth and impaired glucose tolerance at age 64","volume":"303","author":"Hales","year":"1991","journal-title":"BMJ"},{"key":"10.1113\/expphysiol.2011.058511-BIB20|cit20","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1161\/01.CIR.0000074229.93804.5C","article-title":"Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase","volume":"107","author":"Hambrecht","year":"2003","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB21|cit21","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1161\/ATVBAHA.107.153288","article-title":"Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers","volume":"27","author":"Hamburg","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1113\/expphysiol.2011.058511-BIB22|cit22","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.2337\/db07-0882","article-title":"Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease","volume":"56","author":"Hamilton","year":"2007","journal-title":"Diabetes"},{"key":"10.1113\/expphysiol.2011.058511-BIB23|cit23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1249\/MSS.0b013e3181607421","article-title":"Television time and continuous metabolic risk in physically active adults","volume":"40","author":"Healy","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1113\/expphysiol.2011.058511-BIB24|cit24","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1152\/japplphysiol.00888.2005","article-title":"Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutrition","volume":"99","author":"Hesse","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/01.CIR.100.11.1194","article-title":"Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide","volume":"100","author":"Higashi","year":"1999","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB26|cit26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1249\/MSS.0b013e3181930355","article-title":"Sitting time and mortality from all causes, cardiovascular disease, and cancer","volume":"41","author":"Katzmarzyk","year":"2009","journal-title":"Med Sci Sports Exerc"},{"key":"10.1113\/expphysiol.2011.058511-BIB27|cit27","doi-asserted-by":"crossref","first-page":"H1070","DOI":"10.1152\/ajpheart.1997.272.3.H1070","article-title":"Four weeks of cycle training increases basal production of nitric oxide from the forearm","volume":"272","author":"Kingwell","year":"1997","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB28|cit28","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0735-1097(01)01439-5","article-title":"The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes","volume":"38","author":"Maiorana","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB29|cit29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0002-8703(96)90346-4","article-title":"Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound","volume":"131","author":"Mano","year":"1996","journal-title":"Am Heart J"},{"key":"10.1113\/expphysiol.2011.058511-BIB30|cit30","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1056\/NEJMoa021067","article-title":"Walking compared with vigorous exercise for the prevention of cardiovascular events in women","volume":"347","author":"Manson","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1113\/expphysiol.2011.058511-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1152\/jappl.1991.70.3.1245","article-title":"Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body","volume":"70","author":"Mikines","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB32|cit32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1600-0838.2009.01012.x","article-title":"The effect of rowing on endothelial function and insulin action in healthy controls and in patients with type 2 diabetes","volume":"21","author":"Olsen","year":"2011","journal-title":"Scand J Med Sci Sports"},{"key":"10.1113\/expphysiol.2011.058511-BIB33|cit33","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1152\/jappl.2000.88.2.761","article-title":"Enhanced endothelium-dependent vasodilation in older endurance-trained men","volume":"88","author":"Rinder","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB34|cit34","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1152\/jappl.1999.87.6.2136","article-title":"Enhanced endothelial vasoreactivity in endurance-trained older men","volume":"87","author":"Rywik","year":"1999","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1161\/01.CIR.0000118500.23649.DF","article-title":"Is slower early growth beneficial for long-term cardiovascular health?","volume":"109","author":"Singhal","year":"2004","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB36|cit36","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1152\/jappl.1987.62.2.606","article-title":"Maximal vascular leg conductance in trained and untrained men","volume":"62","author":"Snell","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB37|cit37","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1152\/japplphysiol.00545.2009","article-title":"Effect of 10 days of bedrest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes","volume":"108","author":"Sonne","year":"2010","journal-title":"J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB38|cit38","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1161\/01.CIR.101.25.2896","article-title":"Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes","volume":"101","author":"Taddei","year":"2000","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB39|cit39","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00421-009-1260-x","article-title":"Impact of inactivity and exercise on the vasculature in humans","volume":"108","author":"Thijssen","year":"2010","journal-title":"Eur J Appl Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB40|cit40","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1440-1681.2005.04188.x","article-title":"Active role for the vasculature in the delivery of insulin to skeletal muscle","volume":"32","author":"Vincent","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1113\/expphysiol.2011.058511-BIB41|cit41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2337\/diabetes.51.1.42","article-title":"Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow","volume":"51","author":"Vincent","year":"2002","journal-title":"Diabetes"},{"key":"10.1113\/expphysiol.2011.058511-BIB42|cit42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.CIR.81.2.491","article-title":"Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease","volume":"81","author":"Vita","year":"1990","journal-title":"Circulation"},{"key":"10.1113\/expphysiol.2011.058511-BIB43|cit43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7326\/0003-4819-130-2-199901190-00002","article-title":"The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men","volume":"130","author":"Wei","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1113\/expphysiol.2011.058511-BIB44|cit44","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.CIR.81.2.482","article-title":"Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis","volume":"81","author":"Yasue","year":"1990","journal-title":"Circulation"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2011.058511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2011.058511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1113\/expphysiol.2011.058511\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T05:21:32Z","timestamp":1626844892000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1113\/expphysiol.2011.058511"}},"subtitle":["Physical inactivity and endothelial function"],"short-title":[],"issued":{"date-parts":[[2011,8,22]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2011.058511","archive":["Portico"],"relation":{},"ISSN":["0958-0670"],"issn-type":[{"value":"0958-0670","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8,22]]}}}