{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:06:06Z","timestamp":1792515966463,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T00:00:00Z","timestamp":1338422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Acute physical activity elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise\u2010induced muscle injuries. In the present time\u2010course study, pigs were submitted to an acute bout of treadmill running until near exhaustion to determine the impact of unaccustomed exercise on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during postexercise recovery. Several members of the heat shock protein family and proteins associated with proteolytic events, such as the muscle\u2010specific E3 ubiquitin ligase atrogin\u20101, were significantly upregulated, suggesting that protein breakdown, prevention of protein aggregation and stabilization of unfolded proteins are important processes for restoration of cellular homeostasis. We also detected an upregulation of genes that are associated with muscle cell proliferation and differentiation, including <jats:italic>MUSTN1<\/jats:italic>, <jats:italic>ASB5<\/jats:italic> and <jats:italic>CSRP3<\/jats:italic>, possibly reflecting activation, differentiation and fusion of satellite cells to facilitate repair of muscle damage. In addition, exercise increased expression of the orphan nuclear hormone receptor NR4A3, which regulates metabolic functions associated with lipid, carbohydrate and energy homeostasis. Finally, we observed an unanticipated induction of the long non\u2010coding RNA transcript <jats:italic>NEAT1<\/jats:italic>, which has been implicated in RNA processing and nuclear retention of adenosine\u2010to\u2010inosine edited mRNAs in the ribonucleoprotein bodies called paraspeckles. These findings expand the complexity of pathways affected by acute contractile activity of skeletal muscle, contributing to a better understanding of the molecular processes that occur in muscle tissue in the recovery phase.<\/jats:p>","DOI":"10.1113\/expphysiol.2011.063727","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T06:01:20Z","timestamp":1329372080000},"page":"833-848","source":"Crossref","is-referenced-by-count":31,"title":["Gene expression profiling of porcine skeletal muscle in the early recovery phase following acute physical activity"],"prefix":"10.1113","volume":"97","author":[{"given":"Jeanette H.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene N.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Hedegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette F.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Oksbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hornsh\u00f8j","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bendixen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.3.289"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1727309"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0605-477a"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00211.2003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki022"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2009.08.031"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00095-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200906113"},{"key":"e_1_2_5_10_1","first-page":"2924","article-title":"\u03b1B\u2010Crystallin in lens development and muscle integrity: a gene knockout approach","volume":"42","author":"Brady JP","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.179"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1139\/H09-067"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00019.2003"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.06.027"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01161.2002"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.021220"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.01.026"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00299.2005"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00346065"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.018689"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2011.03.055"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.203"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000056522.82563.5F"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251541198"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00094.2009"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/H09-023"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060250"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg434"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1198\/004017004000000563"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5220"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.2527\/1993.714930x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90923.2008"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351306"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.2.E332"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.8.4750"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00151.2006"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00553.2009"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00679.2007"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3149fje"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00847.2007"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2140"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00528.2001"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00046.2006"},{"key":"e_1_2_5_46_1","first-page":"435","article-title":"The structure of the satellite cells in skeletal muscle","volume":"99","author":"Muir AR","year":"1965","journal-title":"J Anat"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.01.005"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201011110"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01445.2006"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90058-8"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21110"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/09064709409410176"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00209.2009"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0015"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1202"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0447"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0309-1740(01)00216-9"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.3.1119"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.9.e36"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-261"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90119-N"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-6226(80)90085-8"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.07.034"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21553"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1027"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-2023(03)00155-5"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.087775.108"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.2.781"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-0929.2006.00356.x"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2002.00922.x"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01295.2009"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1980com"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656730903315831"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2993"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01007.2009"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2009.07.019"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2009.06.028"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-10-r61"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2011.063727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.2011.063727","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.2011.063727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T19:49:33Z","timestamp":1698695373000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.2011.063727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,31]]},"references-count":77,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1113\/expphysiol.2011.063727"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.2011.063727","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,31]]}}}