{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:14:23Z","timestamp":1790147663047,"version":"4.0.1"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T00:00:00Z","timestamp":1337299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Thermally induced eccrine sweating is cholinergically mediated, but other neurotransmitters have been postulated for psychological (emotional) sweating. However, we hypothesized that such sweating is not noradrenergically driven in passively heated, resting humans. To test this, nine supine subjects were exposed to non\u2010thermal stimuli (palmar pain, mental arithmetic and static exercise) known to evoke sweating. Trials consisted of the following four sequential phases: thermoneutral rest; passive heating to elevate (by \u223c1.0\u00b0C) and clamp mean body temperature and steady\u2010state sweating (perfusion garment and footbath); an atropine sulphate infusion (0.04 mg kg<jats:sup>\u22121<\/jats:sup>) with thermal clamping sustained; and following clamp removal. Sudomotor responses from glabrous (hairless) and non\u2010glabrous skin surfaces were measured simultaneously (precursor and discharged sweating). When thermoneutral, these non\u2010thermal stimuli elicited significant sweating only from the palm (<jats:italic>P<\/jats:italic> &lt; 0.05). Passive heating induced steady\u2010state sweating ranging from 0.20 \u00b1 0.04 (volar hand) to 1.40 \u00b1 0.14 mg cm<jats:sup>\u22122<\/jats:sup> min<jats:sup>\u22121<\/jats:sup> (forehead), with each non\u2010thermal stimulus provoking greater secretion (<jats:italic>P<\/jats:italic> &lt; 0.05). Atropine suppressed thermal sweating, and it also eliminated the sudomotor responses to these non\u2010thermal stimuli when body temperatures were prevented from rising (<jats:italic>P<\/jats:italic> &gt; 0.05). However, when the thermal clamp was removed, core and skin temperatures became further elevated and sweating was restored (<jats:italic>P<\/jats:italic> &lt; 0.05), indicating that the blockade had been overcome, presumably through elevated receptor competition. These observations establish the dependence of both thermal and non\u2010thermal eccrine sweating from glabrous and non\u2010glabrous surfaces on acetylcholine release, and challenge theories concerning the psychological modulation of sweating. Furthermore, no evidence existed for the significant participation of non\u2010cholinergic neurotransmitters during any of these stimulations.<\/jats:p>","DOI":"10.1113\/expphysiol.2012.065037","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T06:22:35Z","timestamp":1334211755000},"page":"930-942","source":"Crossref","is-referenced-by-count":69,"title":["The cholinergic blockade of both thermally and non\u2010thermally induced human eccrine sweating"],"prefix":"10.1113","volume":"97","author":[{"given":"Christiano A.","family":"Machado\u2010Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"McLennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lillioja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne N.","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel A. 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